Solé Solé, Judith (Date of defense: 2022-06-03)
Following the laws of evolution, bacteria are capable of slowly but inexorably acquiring resistance to antibiotic compounds that we have been using for decades. Therefore, bacteria that seemed harmless ...
Gandioso Ubieto, Albert (Date of defense: 2018-11-12)
In the present Thesis, it has been carried out the development of new chemical tools for the diagnosis and treatment of cancer through the use of light as an external factor. On the one hand, light can ...
Fuster Juncà, Cristina (Date of defense: 2019-06-14)
The research work presented in this thesis aims to understand the transport mechanism of two described BBB-shuttles, THRre and MiniAp-4. To achieve these objectives, different techniques have been used ...
Vázquez Bigas, Guillem (Date of defense: 2019-03-22)
Alzheimer’s disease (AD), for which no cure is known yet, is currently the most prevalent cause of dementia for the elderly population. The aberrant aggregation of β-amyloid peptide (Aβ) is believed to ...
Iruela Martin, Guillermo (Date of defense: 2021-09-16)
c-Src tyrosine kinase is associated with poor prognosis in many cancer processes. Although inhibitors of c-Src kinase activity are known, they have not reached success in clinical trials because of lack ...
Segovia Laserna, Rosario (Date of defense: 2022-03-08)
After decades of exorbitant antibiotic misuse and overuse in human medicine, agriculture and livestock industry, multidrug resistant bacteria (MDR) have become a major medical concern. In this regard, ...
Lobo Ruiz, Ariadna (Date of defense: 2019-05-10)
Peptides and proteins are essential substances for living organisms, as they can be found in every cell and tissue and are involved in many biological and physiological processes. Given their intrinsic ...
Duran Corbera, Macarena (Date of defense: 2021-09-30)
Investigacions recents en el camp de la biomedicina han demostrat que les interaccions entre pèptids i macromolècules com ara les proteïnes, modulen i regulen processos biològics importants com la ...
Agramunt Pi, Jordi (Date of defense: 2019-11-08)
2,2-Disubstituted cyclopent-4-ene-1,3-diones (CPDs), which have been as non-hydrolysable maleimide analogs, have been found to possess an unexpected reactivity with N-terminal cysteines. Whilst maleimides ...
Pascual i Pérez, Marina (Date of defense: 2023-11-10)
[eng] Multidrug resistant bacteria have grown to be a significant medical concern as a result of decades of excessive antibiotic usage and overuse in human medicine, agriculture, and the animal industry. ...