Byrom, Daniel (Date of defense: 2018-11-23)
During this doctoral thesis, we have synthesised hundreds of grams of the TGF-β inhibitor LY2157299 (Galunisertib). This product was used by the group of Eduard Batlle in their investigations into the ...
Presa i Rodríguez, Andreu (Date of defense: 2016-12-16)
The photoactivation of metal complexes with potential anticancer activity is a hot topic of current research, as it may lead to the development of more selective and efficient drugs. Photoactivated ...
Vázquez Bigas, Guillem (Date of defense: 2019-03-22)
Alzheimer’s disease (AD), for which no cure is known yet, is currently the most prevalent cause of dementia for the elderly population. The aberrant aggregation of β-amyloid peptide (Aβ) is believed to ...
Iruela Martin, Guillermo (Date of defense: 2021-09-16)
c-Src tyrosine kinase is associated with poor prognosis in many cancer processes. Although inhibitors of c-Src kinase activity are known, they have not reached success in clinical trials because of lack ...
Escolà Jané, Anna (Date of defense: 2018-11-09)
Somatostatin (SST or SRIF14) is a peptidic hormone secreted throughout the central nervous system and in the gastrointestinal tract which has anti-secretory, anti-proliferative and anti-angiogenic ...
Coines Lopez-Nieto, Juan (Date of defense: 2021-01-20)
Carbohydrates are essential molecules in biotechnology and for the proper functioning of living organisms. They are involved in energy storage, being structural components or participating in crucial ...
Torres Yeste, Pol (Date of defense: 2022-12-20)
[eng] Visible-light photocatalysis is currently one of the hottest research areas in organic chemistry, due to the possibility that offers to form C-C and C-Het bonds in a green, non-toxic and efficient ...
Gómez Palomino, Alejandro (Date of defense: 2018-11-27)
In the present Thesis we continued a previous study of the nucleophilic character of titanium(IV) enolates. Particularly,we focused our attention on the analysis of substrate-controlled Michael additions ...
Mancinelli, Andrea (Date of defense: 2017-04-21)
The development of selective methods for the direct conversion of carbon−hydrogen bonds into carbon-heteroatom and carbon−carbon bonds remains a critical challenge in organic chemistry. An interesting ...
Faustino Brissos, Rosa Maria (Date of defense: 2018-04-13)
The discovery of cisplatin and its successful use as chemotherapeutic agent have encouraged the development of metal-based anticancer molecules. The present doctoral research project includes three ...