Segovia Laserna, Rosario (Date of defense: 2022-03-08)
After decades of exorbitant antibiotic misuse and overuse in human medicine, agriculture and livestock industry, multidrug resistant bacteria (MDR) have become a major medical concern. In this regard, ...
Monlleó Mas, Ester (Date of defense: 2016-11-25)
Gaucher disease (GD) is one of the most prevalent lysosomal storage diseases.A mutation on gene gba1 generates a misfolded enzyme acid β-glucosidase. Due to this, this enzyme is not properly transported ...
Mohammad Jabeen, Irrem Laareb (Date of defense: 2021-09-23)
c-Src is a non-receptor tyrosine kinase that controls numerous cellular signaling pathways. c-Src implication in human cancers was brought into the attention in the 1980s. Since its discovery, ...
Martín Rodríguez, Alejandro (Date of defense: 2021-09-15)
In this doctoral thesis a series of computational and experimental studies of molecular magnetoresistance devices at room temperature is presented. This sort of devices is included in the molecular ...
Kennington, Stuart (Date of defense: 2020-12-21)
This thesis focuses on the search for new methodologies for the direct, stereoselective and catalytic formation of carbon-carbon bonds through the formation of chiral nickel(II) enolate species and the ...
Brun Cubero, Omar (Date of defense: 2016-07-27)
An alternative allowing diene-derivatised polyamides to be used in Diels-Alder conjugation reactions has been explored and developed. In this methodology, conjugation takes place between a fully protected, ...
Lobo Ruiz, Ariadna (Date of defense: 2019-05-10)
Peptides and proteins are essential substances for living organisms, as they can be found in every cell and tissue and are involved in many biological and physiological processes. Given their intrinsic ...
Mir Morro, Bartomeu (Date of defense: 2019-11-22)
Given the increasing interest in i-motif structures, obtaining such structures as well as detailed structural information under physiological conditions have become hot topics in the structural biology ...
Agramunt Pi, Jordi (Date of defense: 2019-11-08)
2,2-Disubstituted cyclopent-4-ene-1,3-diones (CPDs), which have been as non-hydrolysable maleimide analogs, have been found to possess an unexpected reactivity with N-terminal cysteines. Whilst maleimides ...
Bellido Muñoz, Marina (Date of defense: 2023-11-03)
[eng] This doctoral thesis aims to explore various synthetic methodologies and their corresponding applications in the field of asymmetric catalysis. More specifically, we have focused on the preparation ...