Gomila Juaneda, Alexandre (Date of defense: 2021-09-20)
The main aim of this thesis is setting up and using in vivo screening techniques to identify and characterize new photopharmacological compounds targeting endogenous proteins. In order to achieve ...
Aparicio Pelegrin, Rosa M. (Date of defense: 2021-04-15)
Els materials porosos polimèrics, també denominats escumes sòlides, són materials sòlids de baixa densitat i elevat volum de porus. Són ben coneguts per la seva varietat d’aplicacions i constitueixen ...
Medina Bernal, Ana del Rocío (Date of defense: 2021-11-19)
Determining and understanding protein structure in atomic detail is a fundamental process to the advancement of biotechnology and biomedicine, shedding light the role of macromolecules and their complexes, ...
Cotrina Celis, Ellen Yadira (Date of defense: 2021-07-06)
La enfermedad de Alzheimer es la principal causa de demencia. Es una enfermedad neurodegenerativa para la cual no existe tratamiento curativo. La transtiretina (TTR) es una proteína tetramérica conocida ...
Escudero Bravo, Paloma (Date of defense: 2021-07-15)
Los transportadores heteroméricos de aminoácidos (HAT) se encuentran compuestos por una subunidad pesada que dirige el tráfico del transportador a la membrana plasmática y la subunidad ligera que posee ...
Pitsili, Eugenia (Date of defense: 2021-11-04)
Metacaspases are a family of cysteine proteases found in lower eukaryotes and plants. They are considered to be distant relatives of caspases, present only in animals. The role of metacaspases is quite ...
Maric, Aida (Date of defense: 2021-11-05)
The circadian clock is an endogenously generated timekeeping mechanism that generates 24-hour rhythms in multiple biological processes. The rhythmic oscillations provide an adaptive advantage, allowing ...
Caballero Muñoz, Iracema (Date of defense: 2021-03-26)
Pathologies that result in highly modulated intensities in macromolecular crystal structures pose a challenge for structure solution. To address this issue two studies have been performed: a theoretical ...
Baeza Lara, Nicolás (Date of defense: 2021-03-13)
La presente Tesis Doctoral se enmarca en el proyecto CTQ2014-59632-R concedido por el ministerio de economía y competitividad al grupo de investigación. El trabajo se ha centrado en caracterizar las ...
Quintairos Domenech, Luis (Date of defense: 2021-07-08)
Despite advances in immunosuppression, allograft rejection and clinical outcomes remain a challenge in solid organ transplantation. Currently, the immunosuppressive treatment’s individual adjustment is ...