Now showing items 243-262 of 284
Ortiz-Maldonado Gibson, Valentín (Date of defense: 2022-10-26)
[spa] En términos generales, el pronóstico de los síndromes linfoproliferativos originados en el linfocito B es francamente desfavorable una vez estos recaen o son refractarios (R/R) a la primera o posteriores líneas de ...
Rabassa Blanco, Judit (Date of defense: 2022-12-16)
[cat] El càncer infantil és una de les principals causes de mortalitat durant la infància i l’adolescència. Segons l’Associació Espanyola contra el càncer, 1500 nens/es de 0 a 14 anys són diagnosticats anualment d’aquesta ...
Moraleda Cibrián, Marta (Date of defense: 2022-07-11)
[eng] INTRODUCTION: One in 700 newborns in the United States is born with cleft palate every year. It is estimated that the prevalence of sleep-disordered breathing symptoms in children with cleft palate, compared with ...
Zamani Mozafarabadi, AmirPasha (Date of defense: 2022-12-16)
[eng] Anti-NMDAR encephalitis is the most frequent antibody-mediated encephalitis known to date, in which patients develop specific antibodies directed against the N-methyl-D-aspartate receptors (NMDARs) in the central ...
Camassa, Alessandra (Date of defense: 2021-07-23)
Understanding the dynamics of the brain that gives rise to conscious experience and that underscore the transition through different brain states is one of the central problems of today’s neuroscience. The cerebral cortex ...
Pallares Pallares, Macià Esteve (Date of defense: 2022-03-08)
Cell migration is essential to many biological processes. In adult organisms, it is crucial for wound healing, homeostasis, and immune response, whereas aberrant cell migration potentially leads to pathology. For example, ...
Stein, Heike (Date of defense: 2020-11-13)
[eng] In this thesis, I investigate different synaptic and circuit mechanisms of working memory, how their interaction produces specific working memory biases, and how their disruption in psychiatric or neurological disease ...
Sevilla Guerra, Sonia (Date of defense: 2018-06-01)
INTRODUCTION: The expansion of professional roles has been proved to be an innovative solution across some countries in order to help address healthcare integration, coordination, continuity, access and health care ...
Bardini, Giulia (Date of defense: 2022-11-30)
[eng] INTRODUCTION: In the last twenty years, sealing cements based on tricalcium silicate cements have been introduced into the market for orthograde filling of the root canal system. These silicate-based sealing cements ...
Vilarrasa Blasi, Roser (Date of defense: 2020-10-09)
[eng] Nuclear organization and its impact on gene regulation have started to be elucidated thanks to the development of chromosomal conformation capture techniques. In this doctoral thesis, in situ Hi-C data and nine ...
Viguera Fernández, Laura (Date of defense: 2022-11-15)
[spa] La primera hipótesis de esta tesis doctoral, establece que la hemoglobina basal (previa al trasplante hepático) y la amplitud máxima del coagulo del tromboelastograma, pueden predecir la transfusión intraoperatoria ...
Mayoral Peñalva, Maria (Date of defense: 2019-07-24)
La epilepsia es una enfermedad con una elevada prevalencia e impacto sociosanitario. Aproximadamente un tercio de los pacientes son resistentes al tratamiento farmacológico y en estos casos debe considerarse la cirugía ...
Carrillo Reixach, Juan (Date of defense: 2022-12-19)
[eng] Pediatric liver cancer is considered a rare disease and represents <3% of all pediatric tumors worldwide. The main types of liver tumors in the pediatric age group are hepatoblastoma (HB) and hepatocellular carcinoma ...
Meneghini, Maria Antonia Emilia (Date of defense: 2021-10-21)
INTRODUCTION: The presence of a donor-specific alloimmune response negatively impacts allograft outcomes, being associated to risk of rejection and premature graft loss. Alloimmunity can be both preformed (memory) or can ...
Amorós Reboredo, Patrícia (Date of defense: 2020-11-26)
ANTECEDENTS DEL TEMA En els últims anys els agents antivirals directes aprovats pel tractament de l’hepatitis C han permès l’accés al tractament a grups de pacients que anteriorment no es tractaven pel risc que comportava ...
Garnica Caparrós, Josep (Date of defense: 2022-11-10)
[spa] Descripción de los eventos transcriptómicos y epigenéticos que tienen lugar en la diferenciación de TFH a TR1 mediada por el tratamiento con nanopartículas decoradas con complejos péptido-MHC, mediante estudios tanto ...
Solé Sánchez, Patricia (Date of defense: 2020-12-09)
[eng] Regulatory cells are essential to immune homeostasis. Both autoimmune diseases and the progression of cancer are related to alterations in the development and/or function of the regulatory compartment. In addition ...
Laroussy El Tayea, Kenza (Date of defense: 2023-12-05)
[spa] INTRODUCCIÓN: El consumo de tabaco sigue siendo el problema de salud pública más importante, ya que representa la principal causa de morbilidad y mortalidad prevenible a nivel mundial. A pesar de conocerse las ...
Moreno Cabrera, José Marcos (Date of defense: 2021-06-17)
This PhD thesis has been carried out with the aim of improving, from a bioinformatic-based approach, the genetic diagnostics of hereditary cancer. More specifically, the aims were: 1. To perform a comprehensive evaluation ...
Montejo Egido, Laura (Date of defense: 2022-06-23)
[spa] Introducción: El trastorno bipolar (TB) es una enfermedad mental crónica y recurrente caracterizada por alteraciones en el estado de ánimo alternándose episodios depresivos con episodios de (hipo)manía y con periodos ...