Mostrando ítems 1-10 de 92
Chiesa, Giulio (Fecha de defensa: 2015-12-11)
Spinal bulbar muscular atrophy (SBMA) is a member of the polyglutamine (polyQ) expansion diseases family; the most famous of which is Huntington disease (HD). SBMA is caused by the expansion of the ...
Mendes Braz, Mariana (Fecha de defensa: 2014-07-07)
La esteatosis hepática es un factor de riesgo en PH bajo I/R, situación quirúrgica normalmente aplicada en la práctica clínica para reducir el sangrado asociado a las resecciones hepáticas. Teniendo en ...
Escobedo Pascual, Albert (Fecha de defensa: 2014-11-06)
Nedd4L is a HECT-type E3 ubiquitin ligase (it covalently binds ubiquitin molecules before transferring them to the final substrate). Ubiquitination is a posttranslational modification (PTM) that labels ...
Cánovas Bilbao, Begoña (Fecha de defensa: 2017-07-20)
In normal epithelial cells, p38α has a well-established role as a tumor suppressor. However, recent reports have illustrated pro-tumorigenic functions for the p38α pathway by promoting tumor cell survival ...
Román González, Lidia (Fecha de defensa: 2014-01-31)
Within the hematopoietic system, all mature blood cells are generated. Every differentiation step is characterized by the activation of a new, lineage specific, genetic program and the extinction of the ...
Bassani, Nicklas (Fecha de defensa: 2017-12-15)
Antiangiogenic drugs are used clinically for treatment of different types of cancers and in the case of renal cell carcinoma (RCC) are now standard first-line treatments (Rini, 2009). Nevertheless, these ...
Ramírez Cota, Rosa María (Fecha de defensa: 2016-07-05)
The depletion of MZT1 in human cells causes severe mitotic spindle defects. Depleted cells lack centrosomal γ-tubulin and arrest in mitosis with a monopolar spindle configuration. Similarly, double ...
Marques, Joana (Fecha de defensa: 2015-12-14)
Malaria is arguably one of the main medical concerns worldwide because of the numbers of people affected, the severity of the disease and the complexity of the life cycle of its causative agent, the ...
Luscieti, Sara (Fecha de defensa: 2016-11-22)
Iron is an essential micronutrient required for many cellular reactions and a tight regulation of its metabolism is therefore crucial for health. Cellular iron homeostasis relies on the coordination of ...
Avó Freixo, Francisco Duque Projecto (Fecha de defensa: 2016-10-20)
The microtubule cytoskeleton plays essential roles during cell division, migration, differentiation, defining cell morphology and organizing intracellular transport. The properties of microtubules, such ...