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Study of the alterations in the intestinal and extra-intestinal microbiome in rats and humans throughout the progression of cirrhosis
La microbiota intestinal desempeña un papel fundamental en el desarrollo del sistema inmune y en el mantenimiento de la homeostasis del huésped suprimiendo las respuestas a los patógenos y reforzando la integridad de las ...
Study of the ammonia absorption process into ammonia/water solutions using polymeric membranes for absorption-resorption refrigeration systems
En aquesta tesi s’estudia el procés d’absorció d’amoníac en dissolucions d’amoníac/aigua utilitzant membranes polimèriques com a contactors per a la seva integració en els sistemes de refrigeració per absorció-resorció. ...
Study of the anticancer activity of a nuclear directed HP-RNase variant and different metal-based compounds
Cancer is the leading cause of death due to non-communicable diseases worldwide. Despite the advances in the development of new antitumor drugs, there are still problems such as the resistance that tumor cells acquire ...
A study of the association between one carbon metabolism and blood pressure in adults and transgenerationally between pregnant women and their children.
El metabolisme monocarbonat i el polimorfisme MTHFR 677 C>T s’ha associat amb la pressió arterial i la hipertensió. Es creu que el mecanisme associat és la programació fetal. Un estat adequat de nutrients del metabolisme ...
Study of the beam induced vacuum effects in the cryogenic beam vacuum chamber of the Future Circular Hadron Collider
The Future Circular Hadron Collider (FCC-hh) is a proposal for a 100 km long hadron collider conceived as the successor of the Large Hadron Collider (LHC). The FCC-hh is designed to reach 50 TeV of beam energy, greatly ...
Study of the biological functions of the nonessential regulatory subunits of the protein phosphatase Glc7 in the yeast Saccharomyces cerevisiae
L’única subunitat catalítica de PP1 en S. cereivisiae, Glc7, interacciona amb un mínim de 31 subunitats reguladores que li permeten regular tot el ventall de funcions. En aquesta tesis, hem estudiat les soques delecionades ...
Study of the characterization of the mechanical properties of materials with elastomeric behavior for biomedical applications
(English) The mechanical characterization of new materials used in the Material Extrusion technique (MEX) in 3D printing is essential. The use of this technique is growing and with it the possible applications of printed ...
Study of the components and adherence to the Mediterranean diet on functional and cognitive ageing: from dietary assessment to a metabolomic approach
[eng] Healthy dietary patterns, such as the Mediterranean diet, have been linked to reduced chronic disease risk and mortality. However, the evidence regarding the impact of healthy dietary patterns on physical and cognitive ...
Study of the components that determine the applicability of pathogenicity predictors in the clinical setting
The translation of Next Generation Sequencing (NGS) technologies from the research field to the clinical setting and, specifically, the results obtained in terms of diagnostic yield remain far from expected. This situation ...
Study of the conformational dynamics of prolyl oligopeptidase
Prolyl oligopeptidase (POP) is an 81-KDa bidomain enzyme which hydrolyses short proline-containing peptides. This enzyme is involved in mnemonic and cognitive processes, and the dysregulation of POP activity is related to ...
Study of the contribution of ORMDL3 to the cannabinoid antitumoral action
Genome-wide association studies have been very useful tools in the last years to relate genes and diseases. Thereby, single nucleotide polymorphisms have been linked to increased ORMDL3 expression and to different pathologies ...
Study of the cooperative effect of UVR, BRAF and LKB1 in melanoma
Entender los mecanismos moleculares relacionados con la melanomagénesis es clave a la hora de encontrar nuevas estrategias preventivas y terapéuticas contra esta letal enfermedad. La epidemiología indica que hay factores ...
Study of the crosstalk between microglia and oligodendrocyte-related cells in central nervous system myelination through interactomics
Els trastorns desmielinitzants com l’esclerosi múltiple (EM) es caracteritzen per la destrucció de la mielina i el deteriorament de la remielinització a causa de fallades en la diferenciació de les cèl·lules progenitores ...
Study of the cytotoxic activity and immunogenicity of the differentiated morphotypes of the genus Mycobacterium, in relation with their cell wall composition
Mycobacterium és un gènere de microorganismes que compren importants patògens de la humanitat, com l’agent etiològic de la tuberculosis, Mycobacterium tuberculosis. Moltes espècies de micobacteris presenten dos morfotips ...
Study of the diffusive properties of extracellular matrix gels used in 3D cultures
The extracellular matrix (ECM) hinders diffusion in both tissues and hydrogels used in 3D cultures. However, how geometric and non-geometric ECM properties contribute to diffusion hindrance remains poorly understood. To ...
Study of the disassembling of the nucleus induced by gossypol in apoptotic nuclear fragmentation-deficient human glioblastoma cells
L’apoptosi, una forma de mort cel·lular regulada, es caracteritza per una cadena d’esdeveniments bioquímics i morfològics orquestrats per una família de proteases anomenades caspases. La posada en marxa de les caspases ...
Study of the dynamic behavior of Pelton Turbines
The future of hydropower is tied to the rapid increase of new renewable energies, such as photovoltaic and wind energy. With the growing share of intermittent electricity production, the operation of hydropower installations ...
Study of the effect of process parameters on the thermophilic anaerobic digestion of sewage sludge, evaluation of a thermal sludge pre-treatment and overall energetic assessment
El consum energètic representa un 30 % dels costos d'operació en sistemes intensius de tractament d'aigües residuals urbanes. En depuradores convencionals que utilitzin un sistema de fangs activats, entorn al 15-20 % de ...
Study of the Electron-Transfer properties of phenolics and their relationship with the biological activity on cancer cells
During aerobic cell metabolism, molecular oxygen is reduced to water through electron-transfer reactions, and the oxygen not completely reduced is transformed into a set of neutral and free radical molecules with high ...
Study of the exfoliation process in epoxy-clay nanocomposites
Cured epoxy resins are highly cross-linked polymers which are increasingly important in high performance engineering field due to the stiffness, high strength, heat resistance and solvent resistance. However one major ...
