Browsing by Title

Drosophila CIC-a: A chloride channel required in the glial niche for neural development

Plazaola Sasieta, Haritz (Date of defense: 2018-11-29)

The chloride channel ClCN2 is expressed in glia in the mature nervous system of vertebrates and some physiological functions have been proposed. In addition, human patients with mutations in the gene or dysfunction of the ...

Drosophila UNR regulates dosage compensation through modulation of RNA-protein interactions

Militti, Cristina (Date of defense: 2013-07-26)

En Drosophila, el desequilibrio en cuanto al contenido de genes ligados al cromosoma X entre hembras (XX) y machos (XY) es corregido mediante la duplicación de la transcripción del único cromosoma X del macho. Este proceso, ...

Drosophila UNR: a factor involved in the translational regulation of dosage compensation

Abaza, Irina (Date of defense: 2006-11-03)

Dosage compensation is a mechanism that equalizes the expression of X-linked genes in those organisms in which males and females differ in the number of X chromosomes. In Drosophila melanogaster, dosage compensation is ...

Drought and flash floods risk assessment methodology

Díaz Loaiza, Manuel Andrés (Date of defense: 2015-11-20)

Floods and Drought are some of the most catastrophic natural disasters for humanity, averaging 1 to 5 billion dollar of annually damage for flood events and 6 to 8 billion dollars respectively for drought events. To avoid ...

Drought variability and change across the Iberian Peninsula

Coll Benages, Joan Ramon (Date of defense: 2013-10-15)

Drought variability and change is assessed in this study across the Iberian Peninsula along the 20th century and the first decade of the 21st century using state of the art drought indices: the Sc-PDSI, the SPI and the ...

Drought-induced die-off in Pinus sylvestris and Quercus ilex forests of Catalonia

Galianao Pérez, Lucía (Date of defense: 2012-03-07)

Los crecientes episodios extremos de sequía asociados al cambio climático someten a los árboles a un fuerte estrés fisiológico que, ocasionalmente, los conduce a una rápida defoliación y a la muerte. En los últimos años, ...

Drug consumption and stressful experiences in adolescent mice: behavioural, neorotoxic and neurochemical responses

Ros i Simó, Clara (Date of defense: 2013-03-15)

Adolescence is a critical developmental period in which the brain emerges from an immature state to adulthood. This process of brain development is associated to greater cognitive capacity but also to altered emotional ...

Drug delivery in photodynamic therapy: From pharmaceutics to animal testing

García Díaz, María (Date of defense: 2012-06-15)

S'ha estudiat el desenvolupament de fotosensibilitzadors i la seva formulació en teràpia fotodinàmica. S'han caracteritzat les propietats fotofísiques dels fotosensibilitzadors porficènics. S'han proposat diferents estratègies ...

Drug design at biological systems level

Remez Vinogradov, Nikita (Date of defense: 2016-02-08)

The explosion of reductionist approaches at the end of the XXth century allowed for fast and high-throughput data collection in pharmaceutical industry, but did not deliver the expected gain in drug discovery performance. ...

Drug development and immunological characterization of Acinetovax, a prophylactic vaccine against resistant nosocomial bacteria Acinetobacter baumannii

Berrio Íñigo, Carlos (Date of defense: 2022-03-04)

Aquesta tesi industrial tenia com a objectiu transferir la vacuna Acinetovax duna companyia biotecnològica a una companyia farmacèutica on pogués ser industrialitzada. Aquesta vacuna va ser desenvolupada per prevenir les ...

Drug Discovery Targeted to Transthyretin Related Amyloidosis

Blasi Pérez, Daniel (Date of defense: 2013-02-27)

Several drug discovery approaches has been performed to find new compounds able to interact with high affinity with the hormone binding site of the homotetrameric protein transthyretin (TTR), and stabilize this tetramer, ...

Drug discovery with a FRET Biosensor of scaffolding interactions in the N-terminal region of c-Src = Descubrimiento de fármacos mediante un biosensor basado en FRET sensible a las interacciones en la región N-terminal de c-Src

Iruela Martin, Guillermo (Date of defense: 2021-09-16)

c-Src tyrosine kinase is associated with poor prognosis in many cancer processes. Although inhibitors of c-Src kinase activity are known, they have not reached success in clinical trials because of lack of selectivity or ...

Drug repurposing of bioenergetic modulators: use in treatment and vaccination of protozoan parasitic diseases

Martínez Flórez, Alba (Date of defense: 2017-06-30)

Las leishmaniasis, la tripanosomiasis Americana y Africana, y la malaria son enfermedades parasitarias que constituyen un importante problema de salud global que afecta mayoritariamente a países en desarrollo. El aumento ...

Drugs of abuse in the aquatic and atmospheric compartments: analysis, occurrence, and assessment of human cosumption in Spain

Mastroianni, Nicola (Date of defense: 2017-09-18)

In the last decades, the development of increasingly sensitive analytical techniques has revealed the presence in the environment of a large number of potentially dangerous compounds for human health and the environment, ...