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Now showing items 29288-29307 of 42435
Molecular mechanisms and effect of acute and psychosocial stress on the intestinal barrier function. Implications on the irritable bowel syndrome
El estrés psicosocial es uno de los grandes problemas de salud en las sociedades modernas. En condiciones fisiológicas el estrés representa una amenaza para la homeostasis. En respuesta al estrés se genera una respuesta ...
Molecular mechanisms during the differentiation, maturation and function of marine fish spermatozoa
The molecular mechanisms regulating sperm differentiation (spermiogenesis) and maturation in fishes are largely unknown. In these oviparous species, the initiation of sperm motility is triggered by the osmolality of the ...
Molecular mechanisms for active DNA demethylation in cellular immune models
Epigenetic factors, such as histone post-translational modifications and DNA methylation, are critical determinants of gene expression, which ultimately defines cell identity and function. Despite intense research in DNA ...
Molecular mechanisms involved in Platinum-Induced Peripheral Neuropathy. An exploratory study
La neuropatia perifèrica induïda per platins (NPIP) és un dels efectes adversos més freqüents del cisplatí, l’oxaliplatí i el carboplatí, agents quimioteràpics de tipus platins administrats pel tractament de càncers altament ...
Molecular mechanisms involved in the cerebral cortex development and their implications in neurodevelopmental disorders
During the process of corticogenesis, cortical radial glial cells (RGs) generate sequentially most of the distinct types of neurons and glial cells that will populate the neocortex. The generation of these cells at the ...
Molecular mechanisms involved in the immunomodulation induced by LIF in cancer
LIF is a pleiotropic cytokine that can act as an immunomodulatory factor in different biological processes, such as embryo implantation, organ transplantation tolerance and multiple sclerosis. Here, we have observed that ...
Molecular mechanisms involved in the process of muscle wasting : human and animal studies
Muscle dysfunction and muscle wasting are major systemic manifestations of chronic conditions such as Chronic Obstructive Pulmonary Disease (COPD) and cancer. Several biological mechanisms contribute to such a dysfunction. ...
Molecular mechanisms involved in the protective effect of Mediterranean diet and olive oil consumption in humans
The scope of the present work was to investigate whether the protective role of the traditional Mediterranean diet (TMD), and virgin olive oil (VOO) rich in phenolic compounds (PC), towards cardiovascular disease can be ...
Molecular mechanisms of ageing in neurodegeneration role of oxidative and endoplamic reticulum stress in different human diseases
La hipòtesi de treball d'aquesta tesi es que les malalties neurodegeneratives<br/>poden considerarse formes accelerades de l'envelliment, selectives per a<br/>determinades localitzacions anatòmiques del teixit nerviós. ...
Molecular mechanisms of alternative splicing regulation by antitumor drugs targeting U2 snRNP
RNA splicing is the process of removal of introns from pre-mRNAs. It is carried out by the spliceosome, composed of five small nuclear ribonucleoproteins (snRNPs). Several small molecules with antitumor properties target ...
Molecular mechanisms of apoptosis induced by dexamethasone in chronic lymphocytic leukemia
Glucocorticoids are frequently included in the chemotherapy regimens administered to patients with CLL because they are potent immunosuppressant agents and because they are able to induce apoptosis in CLL cells. Although ...
Molecular mechanisms of apoptosis induction by AICAR and the new prohibitin-binding compound fluorizoline
The pro-apoptotic effects of two new drugs have been studied for the development of new strategies for cancer treatment. On the one hand, we proved that AICAR induces apoptosis in an AMPK- and p53-independent manner in ...
Molecular mechanisms of msl2 mRNA translational regulation
Regulation of msl2 translation is a key step in the modulation of X-chromosome dosage compensation. MSL2 is the limiting subunit of the dosage compensation complex, an assembly that promotes hyper-transcription of the ...
Molecular mechanisms of plastidial differentiation
Los carotenoides son isoprenoides que tanto los organismos fotosintéticos como algunos no fotosintéticos producen. Tienen funciones relacionadas con la fotosínte sis, la fotoprotección, la señalización y la pigmentación. ...
Molecular mechanisms of resistance to PI3K inhibitors
The development of high-throughput sequencing technologies has prompted the evaluation of large cohorts of different tumor types. The results from these comprehensive genomic studies have revealed the most commonly mutated ...
Molecular mechanisms of resistance to therapy in glioblastoma
[cat] El glioblastoma (GBM) és el tumor primari cerebral més freqüent i més agressiu. Els pacients amb GBM tenen una supervivència mitjana de 15 mesos. Una dels principals dificultats que presenten els GBMs per ser tractats ...
Molecular mechanisms of Smc5/6 complex function: from ATPase-dependent DNA loading to E3 activities
Els cromosomes han de ser manipulats amb compte per mantenir la integritat del genoma. La família de complexos proteics SMC contribueix a organitzar el genoma en llaços de cromatina, utilitzant la seva activitat d'ATPasa ...
Molecular mechanisms regulated by the transcriptional coactivator CRTC1 in synaptic plasticity
La remodelació sinàptica depenent d’activitat o plasticitat sinàptica és considerada la base cel·lular de diferents processos fisiològics cerebrals com l’aprenentatge i la memòria. Un proteoma equilibrat és essencial per ...
Molecular mechanisms regulating osteoblast differentiation: miR-322/Tob2 and PI3K/SMAD networks
We propose a molecular description of the mechanism whereby the osteogenic master gene Osx is controlled post-transcriptionally through a mechanism driven by miR-322/Tob2, strongly suggesting that control of specific mRNA ...
Molecular mechanisms underlying presenilin-dependent tau pathology in neurodegeneration
La malaltia d’Alzheimer (MA), la major causa de demència mundial, es caracteritza per la pèrdua gradual de cognició, especialment de memòria, i per dèficits neuropsiquiàtrics i en el comportament. Les característiques ...
