Browsing by Title

Identification of novel histone marks required for the transcriptional stress response

Martínez Cebrián, Gerard (Date of defense: 2019-12-03)

Upon environmental stresses such as temperature fluctuations or increases in osmolarity, yeast Saccharomyces cerevisiae induces a transcriptional reprograming in order to survive and adapt to the stress. Histone ...

Identification of Novel Immunomodulatory Strategies to Tackle HIV-1 Persistence

Ezeonwumelu, Ifeanyi Jude (Date of defense: 2022-09-30)

La teràpia antiretroviral (TAR) ha millorat dràsticament l'esperança de vida de les persones amb VIH (PLWH), però no és curativa i s'ha de prendre tota la vida. La persistència del VIH en reservoris latents transcripcionalment ...

Identification of novel mechanisms in human breast cancer lung metastasis and chemoresistance

Arenas Lahuerta, Enrique Javier (Date of defense: 2017-04-07)

Breast Cancer (BC) is one of the major causes of cancer deaths in women. BC is a heterogeneous disease, and within the heterogeneity of the tumor, Tumor-Initiating Cells (TICs) have been reported as important drivers in ...

Identification of novel NEK9 substrates and functions through the use of genetically engineered mice. Novel roles in the control of the centrosome cycle

Martínez Delgado, Paula (Date of defense: 2018-10-11)

Mitosis is a process that ensure the correct distribution of the chromosomes between the two newly generated cells, is tightly regulated by two main processes, protein degradation controlled by the APC and protein ...

Identification of novel signaling pathways for cardiomyocyte differentiation and growth

Ye, Junmei (Date of defense: 2012-12-17)

Identification of novel therapeutic targets and evaluation of pharmacological treatments in epigenetic and chromatin diseases- the case of Rett syndrome

Szczesna, Karolina (Date of defense: 2014-09-26)

INTRODUCTION: In 1966, Rett syndrome (RTT, OMIM#312750) was for the first time described as a clinical issue by Dr. Andreas Rett, an Austrian pediatrician. He has observed in 22 patients similar unique symptoms. A few ...

Identification of novel therapeutic targets and tumor suppressor genes in colon cancer using genome-wide high‐throughput approaches

Bazzocco, Sarah (Date of defense: 2016-01-27)

Colorectal cancer is a disease caused by genetic and epigenetic changes. Inactivation of tumor suppressor genes and activation of oncogenes are key landmarks in tumor progression. However, the list of tumor suppressor genes ...

Identification of oxidative stress susceptibility-related genes in cystic fibrosis airway epithelial cells through functional genomics using a randomized siRNA library

Checa Raya, Javier (Date of defense: 2021-03-26)

INTRODUCTION: Pulmonary manifestations are the main cause of morbidity and mortality in more than 90 % of cystic fibrosis (CF) patients who exceed the neonatal period. The chronic immune-inflammatory process, exacerbated ...

Identification of plastic material constituents in water and development of migration assays

Guart Torres, Albert (Date of defense: 2013-10-31)

The thesis with title "Identification of plastic material constituents in water and development of migration assays" has as the main objective the identification of the plastic components in the water for human consumption ...

Identification of proteomic biomarkers for the prediction of implant biological responses

Romero Gavilán, Francisco Javier (Date of defense: 2018-12-11)

Dada la creciente necesidad en implantología de desarrollar biomateriales con mejores propiedades, resulta crucial su óptima producción y caracterización. Así tras su implantación en el cuerpo, estos entran en contacto ...

Identification of snow avalanche release areas and flow characterization based on seismic data studies

Roig-Lafon, Pere (Date of defense: 2021-06-10)

The main objectives of this PhD thesis are the identification of the snow avalanche release areas and the snow avalanche flow regime characterization with the use of seismic data. We aim to search for new methods for ...

Identification of suppressors of the constitutive photomorphogenic phenotype of pifq: from chloroplasts to rhythmic growth

Martín Matas, Guiomar (Date of defense: 2015-11-27)

Plants germinated in the dark under the soil surface, undergo skotomorphogenic development. Once they emerge from the soil surface perceive light for the first time. Then, seedlings switch from skotomorphogenic to ...

Identification of the interaction networks of Mitofusin-1 and Mitofusin-2 = Identificació de les xarxes d’interacció de Mitofusina-1 i Mitofusina-2

Gordaliza Alaguero, Isabel (Date of defense: 2021-11-29)

Mitofusins (MFN1/2) have been demonstrated to play a role in several mitochondrial functions such as mitochondrial dynamics and bioenergetics, interorganelle communication, immune response, autophagy, cell cycle progression, ...

Identification of the sphingolipid desaturase DEGS1 as a novel gene for a leukodystrophy in therapeutic hope

Pant, Devesh Chandra (Date of defense: 2018-10-05)

In spite of recent advances in understanding the genetic bases of leukodystrophies, a large number of clinical cases remain unexplained, suggesting that many leukodystrophy-associated genes have yet to be identified. Here ...

Identification of time- and sex-dependent pathways involved in renal ischemia-reperfusion injury in a porcine model. Link to renal cancer

Nemours, Stéphane (Date of defense: 2020-07-29)

Les malalties renals es deriven de defectes congènits, lesions renals agudes (AKI) o malalties renals cròniques (CKD), entre altres causes. La lesió renal d’isquèmia /reperfusió (IRI), que es troba en moltes situacions ...