Mostrando ítems 3137-3156 de 3232
Serrat Farran, Xènia (Fecha de defensa: 2019-11-26)
Caenorhabditis elegans provides a powerful experimental system for understanding fundamental questions in biomedical research, including the consequences of pre-mRNA splicing alterations. Here, we have applied CRISPR and ...
Martínez Høyer, Sergio (Fecha de defensa: 2012-10-11)
The calcineurin-NFATc signaling pathway is involved in many aspects of the development and function of the immune, neural, skeletal, cardiovascular and muscular system of vertebrates. Regulators of Calcineurin (RCAN) ...
Cavazza, Tommaso (Fecha de defensa: 2015-10-30)
To ensure faithful segregation of the genetic material, during mitosis the cell assembles the mitotic spindle, a macromolecular machine made of dynamic microtubules and associated proteins. Spindle microtubules are assembled ...
Colomer Montañà, Carlota (Fecha de defensa: 2017-12-21)
Numerous studies have shown that the protein kinase IKKα is associated with cancer progression and metastasis in different models. However, the mechanisms underlying IKKα tumorigenic functions are poorly understood. We ...
Sierra Noguera, Cèsar (Fecha de defensa: 2022-03-18)
The presence of an extra copy of Human Chromosome 21 (HSA21) in Down syndrome (DS) is one of the most complex genetic perturbations compatible with life and is the most common genetic cause of intellectual disability. Here, ...
Horváth, Vivien (Fecha de defensa: 2020-09-28)
Environmental stress is a major aspect of life and a limiting factor for the survival and distribution of species. Understanding the organismal stress response and the developed coping mechanisms is indispensable in order ...
Poliński, Patrik (Fecha de defensa: 2022-04-07)
Microexons are an unusual form of alternative splicing with high evolutionary conservation, however, their functions are still far from being understood. In this thesis, we focused on a neuronal-specific microexon that ...
Calderón-Benavides, Liliana (Fecha de defensa: 2011-09-27)
This doctoral work focuses on identifying and understanding the intents that motivate a user to perform a search on the Web. To this end, we apply machine learning models that do not require more information than the one ...
Nikbakht Silab, Rasoul (Fecha de defensa: 2021-03-17)
This thesis studies parametric optimization in cellular and cell-free networks, exploring data-based and expert-based paradigms. Power allocation and power control, which adjust the transmit power to meet different fairness ...
Martín de Dios, Laura (Fecha de defensa: 2024-05-06)
La organización del genoma en células mamíferas sigue siendo en gran parte desconocida. Un nivel fundamental de organización se considera el bucle de cromatina, que consiste en una región de ADN atrapada en el interior ...
López Escardó, David (Fecha de defensa: 2018-01-15)
Opisthokonta is an eukaryotic supergroup that contains Metazoa, Fungi and their unicellular relatives. Therefore, this group provides an ideal framework to study distinct unicellular-multicellular transitions, among them, ...
Belmonte Mateos, Carla (Fecha de defensa: 2022-02-03)
Precise regulation of neurogenesis is achieved by differentially allocating the neurogenic competence along the tissue. In the hindbrain proneural gene expression is stereotypically confined in segment boundary-adjacent ...
Engel-Pizcueta, Carolyn (Fecha de defensa: 2023-04-28)
The generation of cell diversity in the embryonic brain relies on the balance between cell proliferation and differentiation. The hindbrain boundary cells specify at the interface between adjacent compartments. Boundary ...
De Bont, Jeroen (Fecha de defensa: 2020-12-11)
Understanding the determinants of childhood obesity has never been more urgent given the high levels across the world. It is increasingly recognized that the urban environment may affect childhood growth and obesity, and ...
Avila-Palencia, Ione (Fecha de defensa: 2018-11-21)
Urban environments are very complex systems with a myriad of factors intricately related. Built environment, transport, physical activity and sedentary behaviours, air pollution, and social contacts and feelings of loneliness ...
Kent, Jonathan (Fecha de defensa: 2023-11-27)
Urban design influences how we go about our lives and even how we feel about our neighbors. Using data from the Copernicus Urban Atlas, I find that residents of cities across Europe that have more continuous urban fabric ...
Mehdipanah, Roshanak (Fecha de defensa: 2014-05-23)
Urban renewal interventions aim to improve physical infrastrucutres, promote social integration and increase economic gains. However, they also have the potential to improve the wellbeing of residents. The objective of ...
Marín, Celia (Fecha de defensa: 2018-01-29)
Press reports and stories about the idea of the asocial have taken place successively in Barcelona since the beginning of the twentieth century. They range from the Lliga Regionalista’s fear of the barbarians to the ...
Cussel, Mattea (Fecha de defensa: 2023-01-23)
The object of study of this thesis is a special case of translation: the Anglophone literature of writers of Caribbean or Latin American origin in the United States translated into Spanish. This case is special because of ...
Segura Puimedon, Maria (Fecha de defensa: 2012-11-20)
Williams-Beuren syndrome (WBS) is a neurodevelopmental disorder caused by the common deletion of 26-28 contiguous genes in the 7q11.23 region, which poses difficulties to the establishment of genotype-phenotype correlations. ...