Universitat Pompeu Fabra
Now showing items 2526-2545 of 3232
Yeast deal with continuous environmental perturbations that compromise its cell fitness. Upon osmostress, HOG pathway becomes activated and leads the adaptation response. To compensate the osmotic imbalance, Hog1 is in ...
The p38 mitogen activated protein kinase (MAPK) has a crucial role in cells’ stress adaptation and survival. It also plays a role in physiological processes such as differentiation of skeletal muscle or in pathologies such ...
Reactive oxygen species (ROS) are a variety of molecules derived from molecular oxygen during different metabolic processes. ROS can react with different cellular components resulting in lipid peroxidation, protein oxidation ...
This thesis consists of three essays on the regulation of Intellectual Property Rights (IPRs) and trade in open economies. The rst chapter investigates the di erences in Intellectual Property Rights between countries. ...
Alternative splicing provides the cell the ability to generate, from a single gene, multiple protein isoforms, sometimes with different or even antagonistic functions. This process is tightly regulated and alterations in ...
This work is centered on the study of the NKG2 C-type lectin-like receptors on NK and CD4+T cells. We provide evidence supporting that CD4+T cells specific for Human Cytomegalovirus (HCMV) may express different NK cell ...
NFAT5 is the main regulator of an osmoprotective gene program that is switched on by osmotic stress. Hypertonicity causes a harmful increase in the intracellular concentration of inorganic ions and NFAT5-regulated genes ...
Alternative pre-mRNA splicing of the Notch regulator NUMB exon 9 switches between isoforms that promote (exon inclusion) or prevent (exon skipping) cell proliferation. We have studied NUMB alternative splicing regulation ...
This project has aimed to investigate the regulation of the mechanosensitive ion channel Piezo1 by proteins that sense and modify membrane curvature. Our second objective has been to study this interplay in the context of ...
CD4+ T cells can adopt specific functional programs in response to changes in microenvironment variables, such as cytokine availability, cell-to-cell contacts and stress conditions. It has been described that the elevation ...
El gen humano 11-HSD2 es un modelo para investigar la contribución de los efectos de los receptores de esteroides en células de cáncer de mama. El análisis del promotor mostró que la región distal está implicada ...
DYRK1A is the most studied member of the DYRK family of protein kinases, because is one of the human chromosoma 21 proteins for which changes in gene dosage result in neuropathological alterations. DYRKs are activated by ...
A Saccharomyces cerevisiae, un increment de la temperatura comporta diversos efectes deleteris en l’organització interna de la cèl∙lula i indueix una inducció ràpida, massiva i transitòria d’expressió gènica, que es ...
This doctoral dissertation examines the role of Independent Regulatory Agencies (IRAs) in the macro institutional setup with an objective to understand what factors affected or continue to affect their functioning after ...
El patró específic d'expressió de glicosiltransferases i antígens Lewis observat a la mucosa gàstrica normal es perd durant el procés de la carcinogènesi gàstrica. Aquí descrivim que canvis en l'expressió dels antígens ...
The c-Myc transcription factor is a key player in cell homeostasis, being commonly deregulated in human carcinogenesis. In this PhD thesis we have addressed the question how regulatory mechanisms restrain the oncogenic ...
Adaptive responses allow cells to maintain their growth as well as their proliferative potential under diverse stress conditions. It is known that, growth and proliferation can be suppressed by intense stress, but maintained ...
This dissertation studies the role of music making in the social construction of the city within the paradigm of the experience economy. Music making as collective organization of sound that requires decisions of what is ...
In this thesis, I argue that Jürgen Haberma’s neo-katian liberalim fails to provide universalistic foundations for truth and morality as it cannot be applied invariably across different context. However, this failure does ...
La incapacidad temporal por contingencia común (ITcc) representa un elevado coste social. Cualquier esfuerzo para desarrollar políticas orientadas a mejorar la gestión de los episodios de ITcc y facilitar el retorno al ...
