Now showing items 1-20 of 3295

    1)Jarid2 regulates mouse epidermal stem cell activation and differentiation ; 2)Tumor heterogeneity and metastasis-initiation in human squamous cell carcinoma 

    Mejetta, Stefania (Date of defense: 2013-09-12)

    Jarid2 is required for the genomic recruitment of the polycomb repressive complex-2 (PRC2) in embryonic stem cells. However, its specific role during late development and adult tissues remains largely uncharacterized. ...

    3D audio technologies : applications to sound capture, post-production and listener perception 

    Cengarle, Giulio (Date of defense: 2012-11-29)

    La llegada del sonido 3D está imponiendo cambios en varias etapas del flujo de trabajo, desde los sistemas de captación hasta las metodologías de postproducción y las configuraciones de altavoces. Esta tesis trata varios ...

    3D reconstruction for plastic surgery simulation based on statistical shape models 

    Ruiz Fernández, Guillermo (Date of defense: 2018-12-12)

    This thesis has been accomplished in Crisalix in collaboration with the Universitat Pompeu Fabra within the program of Doctorats Industrials. Crisalix has the mission of enhancing the communication between professionals ...

    3D reconstruction of the proximal femur and lumbar vertebrae from dual-energy x-ray absorptiometry for osteoporotic risk assessment 

    Whitmarsh, Tristan (Date of defense: 2012-09-25)

    In this thesis a method was developed to reconstruct both the 3D shape and the BMD distribution of bone structures from Dual-energy X-ray Absorptiometry (DXA) images. The method incorporates a statistical model built from ...

    3D subject-specific shape and density modeling of the lumbar spine from 2D DXA images for osteoporosis assessment 

    López Picazo, Mirella (Date of defense: 2019-03-19)

    Osteoporosis is the most common bone disease, with a significant morbidity and mortality caused by the increase of bone fragility and susceptibility to fracture. Dual Energy X-ray Absorptiometry (DXA) is the gold standard ...

    A 3D culture system to study gene regulation in breast cancer cells 

    Ramírez Cuéllar, Angélica Julieta (Date of defense: 2022-05-12)

    In this Thesis we report the successful growth of hormone responsive T47D cells as 3D spheroids in Matrigel mimicking the ECM. A detailed characterization by using a genome-wide approach of the main physical and biochemical ...

    A 3D multi-modal approach to study neuronal differentiation and tissue growth in the zebrafish hindbrain 

    Blanc, Matthias (Date of defense: 2024-07-19)

    The process by which the diversity of neurons making up the brain are produced relies on precise adjustments across space and time. Proneural genes are main drivers of neurogenesis across the different areas of the brain ...

    A Bioinformatics approach to the study of comorbidity : Insight into mental disorders 

    Gutiérrez-Sacristán, Alba (Date of defense: 2017-12-15)

    Estudios clínicos y epidemiológicos muestran que la comorbilidad, la coexistencia de varias enfermedades en un mismo paciente, tiene un gran impacto en la evolución de su estado de salud. Por lo tanto, el análisis de ...

    A Comprehensive multiomics approach towards understanding obsessive-compulsive disorder 

    Domènech Salgado, Laura (Date of defense: 2018-12-20)

    To date, very little progress has been made towards elucidating the genetic causes of obsessive-compulsive disorder (OCD). In this project we have performed rare variant association study (RVAS) transcriptomics and ...

    A Comprehensive screening of X-linked and miRNA-driven signatures of positive selection and the role of cis-regulatory elements in the human genome 

    Villegas Mirón, Pablo (Date of defense: 2021-07-19)

    The evolutionary history of the human genome has been shaped by the selection of multiple elements in response to different environmental pressures. The analysis of regulatory adaptations and the particularities of sexual ...

    A Comprehensive study of arithmetic circuits and elliptic curves for efficient and scalable zero-knowledge proof systems 

    Bellés Muñoz, Marta (Date of defense: 2023-10-10)

    In recent years, zero-knowledge proofs have come to play a crucial role in distributed systems where there is no trust between the parties involved. Most popular proof systems are for the NP-complete language of arithmetic ...

    A computational approach to rhythm description - Audio features for the computation of rhythm periodicity functions and their use in tempo induction and music content processing 

    Gouyon, Fabien (Date of defense: 2005-11-30)

    Aquesta dissertació tracta del ritme musical. Més exactamente, tracta de programes informàtics que extreuen automàticament descripcions rítmiques a partir de senyals musicals d'àudio.<br/>Presentem nous algorismes per a ...

    A computational approach to studying interdependence in string quartet performance 

    Papiotis, Panagiotis (Date of defense: 2016-02-01)

    This dissertation proposes a computational data-driven methodology to measure music ensemble interdependence - the degree to which musicians interact and influence each other’s actions in order to achieve a shared goal - ...

    A Computational toolkit to boost precision oncology with pharmacogenomics 

    Mateo Ramos, Lídia (Date of defense: 2019-12-18)

    Durant la darrera dècada la seqüenciació massiva de pacients de cancer ha permés avançar de forma significativa el coneixement sobre les bases moleculars del càncer. Un cop assolit aquest primer pass, el repte que tenim ...

    A cross-layer mechanism for QoS improvements in VoIP over multi-rate WLAN networks 

    Sfairopoulou, Anna (Date of defense: 2008-07-28)

    In IEEE 802.11 WLANs, Link Adaptation mechanisms, which choose the transmission rate of each node, provoke unexpected and random variations on the effective channel capacity. When these changes are towards lower bitrates, ...

    A Cross-linguistic comparison of the verbs of speaking with the component of non-standard speech and their translation (English-Russian) 

    Pasenkova, Irina (Date of defense: 2020-07-02)

    In this dissertation we examine the sphere of the English verbs of speaking (VoS) with 2 components: the manner of speaking component (MoSC) and the component of non-standard speech (CoNS), and their translations from ...

    A Discurse afterlife: representations of the political life, death, and continued presence of Marielle Franco] 

    de la Presa, Lucia (Date of defense: 2024-03-05)

    This dissertation is an exploration of discourses representing the political life, death, and continued presence of Marielle Franco following her assassination on 14 March 2018. Marielle Franco was a councilwoman in the ...

    A dynamic Turing model of digit patterning : a Turing mechanism modulated by positional information underlies digit specification 

    Marcon, Luciano (Date of defense: 2013-11-05)

    The specification of the vertebrate limb skeleton is a classical model to study pattern formation during development. Two different theories have been proposed to explain this process: the Turing mechanism and the ...

    A functional study of the conserved LSM proteins in C. elegans reveals their involvement in the stress response of metazoans 

    Cornes Maragliano, Eric (Date of defense: 2015-07-24)

    Lsm proteins regulate RNA metabolism and are conserved in the three domains of life, typically functioning as RNA-binding complexes involved in a wide range of post-transcriptional mechanisms. Generally, their functions ...

    A Genome-wide CRISPR screen to identify novel pathways involved in reprogramming and x-chromosome reactivation 

    Barrero Asencio, Mercedes (Date of defense: 2023-03-02)

    During reprogramming of somatic cells into induced pluripotent stem cells (iPSCs), the epigenome needs to be reset. A prime example of this is the reversal of the silent state of the inactive X chromosome in female cells, ...