Serrat Farran, Xènia (Date of defense: 2019-11-26)
Caenorhabditis elegans provides a powerful experimental system for understanding fundamental questions in biomedical research, including the consequences of pre-mRNA splicing alterations. Here, we have ...
Marín López, Manuel Alejandro (Date of defense: 2017-01-13)
Proteins are involved in almost all cell processes, with physical interaction between them being key to their function and dictated by its 3D structure. Hence, the study of protein-protein interactions ...
Radchenko, Tatiana L. (Date of defense: 2018-09-28)
The work of this thesis aims to develop of a new workflow to predict potential Sites of Cleavage (SoCs) in new candidate peptide drugs. The main goal of this workflow is to understand the protease ...
Generoso, Serena Francesca (Date of defense: 2019-03-21)
X-Chromosome Reactivation (XCR) occurs in the epiblast cells of the blastocyst and in germ cells, thereby coupling XCR with pluripotency. We performed a screen in iPS cells by knocking down the expression ...
Ferruz Capapey, Noelia (Date of defense: 2016-03-04)
Understanding how receptor-ligand interactions occur is a first step towards designing new drugs. The complete reconstruction of the binding process in a drug-receptor system provides all the ...
Balsiger, Alexander (Date of defense: 2014-12-19)
We recently identified a novel cyclin called Cyclin O which is able to bind and activate Cdk1 and Cdk2 in response to intrinsic apoptotic stimuli like DNA damage or ER stress. Cyclin O has been shown ...
Blasco Moreno, Bernat (Date of defense: 2016-06-03)
The exonuclease Xrn1 degrades messenger RNAs (mRNAs) and controls transcription. By using a model system that replicates brome mosaic virus (BMV) in yeast, here we show that Xrn1 promotes translation ...
Rodríguez Torrecillas, Ivan (Date of defense: 2015-12-14)
ABC (ATP-binding cassette) transporters are involved in translocate a wide spectrum of molecules across the lipid bilayer and some of them are associated with various diseases. They also have an ...
Calvo Arnedo, María Isabel (Date of defense: 2012-12-21)
En el laboratorio se utiliza como sistema modelo la levadura Schizosaccaromyces pombe para poder estudiar la respuesta a estrés oxidativo. Las dos rutas principales de respuesta a estrés oxidativo son ...
Paulo Mirasol, Esther (Date of defense: 2014-12-19)
Reactive oxygen species (ROS) are a variety of molecules derived from molecular oxygen during different metabolic processes. ROS can react with different cellular components resulting in lipid peroxidation, ...