Drews-Elger, Katherine (Date of defense: 2008-11-07)
The transcription factor NFAT5/TonEBP belongs to the Rel family, which also comprises NF ÛB and NFATc proteins. NFAT5 only shares structural and functional homology with other Rel family members at the ...
Amaral, Nuno (Date of defense: 2016-01-22)
La coordinació de la citocinesis amb la segregació cromosòmica és essencial per mantenir l’estabilitat cromosòmica durant la proliferació cel•lular. Tant en llevat com en cèl•lules animals, els ponts ...
Pittis, Alexandros (Date of defense: 2016-10-14)
The origin of eukaryotic compartmentalization stands as a major conundrum in biology. Current evidence indicates that the last eukaryotic common ancestor (LECA) already possessed many eukaryotic hallmarks, ...
Titos Vivancos, Iris (Date of defense: 2013-10-25)
At the metaphase-to-anaphase transition, spindle microtubules pull replicated chromosomes to the daughter cells, but full separation of long chromosome arms is achieved in late anaphase. We have created ...
Porta de la Riva, Montserrat (Date of defense: 2009-09-22)
La transició epiteli-mesènquima (TEM) és un procés en què cèl lules epitelials, immòbils i amb polaritat apico-basal transiten cap un fenotip mesenquimal o fibroblàstic. L'expressió del factor de ...
Morral Martínez, Clara (Date of defense: 2017-07-17)
El càncer de colon es caracteritza per presentar una composició cel·lular heterogènia en la qual només un subgrup de cèl·lules retenen la capacitat de contribuir en el manteniment i creixement del tumor. ...
Pich Roselló, Oriol (Date of defense: 2021-03-24)
Cells of our body are constantly exposed to events that can create lesions in the DNA. If unremoved by the DNA repair mechanisms, the lesion may lead to a mutational event. Some of these events might ...
Pecoraro, Matteo (Date of defense: 2014-10-02)
La senescencia celular es una detención irreversible del ciclo celular que tiene lugar en respuesta a diversos estímulos de estrés, actuando como un mecanismo supresor de tumores para impedir la ...
Ros i Rocher, Núria (Date of defense: 2019-02-15)
The origin of animal multicellularity is a major evolutionary question. Recent genome data from the closest extant unicellular relatives of animals revealed that they actually possess and express a ...
Cabrerizo Granados, David (Date of defense: 2020-11-30)
Snail1 is a transcriptional factor with a great relevance in tumor development as it is required for epithelial to mesenchymal transition and activation of cancer-associated fibroblasts (CAF). In this ...