Bosch Gutiérrez, Almudena (Date of defense: 2009-12-21)
The Polycomb group (PcG) family of proteins form chromatin-modifying complexes essential for embryonic development, and stem cell renewal and are commonly deregulated in cancer. There are several reports ...
Escoté Miró, Xavier (Date of defense: 2005-10-06)
Exposure of yeast to increases in extracellular osmolarity activates the stress-activated Hog1 MAP kinase, which is essential for cell survival upon osmotic stress. Activation of the Hog1 MAPK results ...
Simonte, Giacoma (Date of defense: 2016-12-14)
My PhD project was focused on understanding if endogenous bone-marrow cells (BMCs) could participate in the repair of mouse retina following N-Methyl-D-aspartate (NMDA) damage. We wanted to explore the ...
Neurohr, Gabriel Erich (Date of defense: 2012-04-13)
Partitioning of chromatids during mitosis requires that chromosome compaction and spindle length scale appropriately with each other. However, it is not clear whether chromosome condensation and spindle ...
Knezevic, Iva (Date of defense: 2015-07-17)
In eukaryotic cells a key regulatory step of cell cycle occurs in late G1, which has been termed “Start” in yeast cells. At this point, cells determine whether they will go to through a new round of ...
Mrkonjić, Sanela (Date of defense: 2014-03-31)
The TRPV4 cation channel is expressed in a broad range of tissues where participates in the generation of a Ca2+ signal. TRPV4 participation in osmo- and mechanotransduction contributes to important ...
Alcaine Colet, Anna (Date of defense: 2019-11-04)
The self-renewing nature of embryonic stem cells (ESCs) is a consequence of their ability to proliferate while maintaining pluripotency, by means the capacity to differentiate into all adult cell types. ...
Navarro Serer, Judith (Date of defense: 2016-12-15)
T-cell homeostasis must be tightly regulated and maintained in order to guarantee appropriate immune responses and prevent immunopathology. This maintenance depends on MHC-TCR interaction and cytokine-mediated ...
Pijuan Calvet, Anna (Date of defense: 2021-09-14)
Yeast deal with continuous environmental perturbations that compromise its cell fitness. Upon osmostress, HOG pathway becomes activated and leads the adaptation response. To compensate the osmotic ...
Alba Castellón, Lorena (Date of defense: 2016-02-17)
Snail transcription factor 1 triggers epithelial to mesenchymal transition. In cancer, this process provides tumoral epithelial cells with invasive characteristics. In this thesis, we demonstrated that ...