Bassaganyas Bars, Laia (Date of defense: 2013-09-20)
Over the last ten years, improvements in molecular techniques and the arrival of the next-generation sequencing technologies have revealed a large amount of structural variation (SV) in the human genome. ...
Heredia Genestar, José María (Date of defense: 2020-01-28)
La mutació és un procés essencial per l’evolució, tot i que també té un rol important tant en el càncer com en altres malalties. Les mutacions no s’acumulen uniformement al llarg del genoma i la seva ...
Alba Castellón, Lorena (Date of defense: 2016-02-17)
Snail transcription factor 1 triggers epithelial to mesenchymal transition. In cancer, this process provides tumoral epithelial cells with invasive characteristics. In this thesis, we demonstrated that ...
García Parra, Jetzabel (Date of defense: 2012-06-21)
Breast cancer is the main cause of cancer death in women. Improved treatments, prevention programs and earlier detection are reducing the rate of death; however, there is still a high percentage of ...
Pérez Llamas, Christian (Date of defense: 2015-12-18)
Given the complexity and heterogeneity of cancer, the development of new high-throughput wide-genome technologies has open new possibilities for its study. Several projects around the globe are ...
Sánchez Osuna, María (Date of defense: 2014-12-19)
Glioblastoma multiforme, one of the most aggressive and lethal tumors, is characterized by a high apoptosis resistance. This doctoral thesis addresses the biochemical behavior of diverse glioblastoma ...
Stanisavljević, Jelena (Date of defense: 2014-07-17)
Carcinomas initiate their invasion hijacking the innate plasticity of both epithelial cells and mesenchymal stromal cells in a reciprocal way. Chemical and mechanical dialogue between stromal fibroblasts ...
Frigola Rissech, Joan (Date of defense: 2020-03-13)
The rate at which mutations accumulate along the genome is not uniform but influenced by factors such as chromatin compactness, replication time or transcription. Most of these factors create mutational ...
Trincado Alonso, Juan Luis (Date of defense: 2019-01-28)
The following thesis tries to answer the question of wheter RNA processing alterations are informative for the clinical management of cancer patients. For this, the work is focused on solve two main ...
Herrero Vicente, Jorge (Date of defense: 2024-02-26)
Cancer cells exhibit a synthetic lethal (SL) phenotype when Myc upregulation is combined with antitumor drugs targeting the splicing factor SF3B1. However, the molecular events and mechanisms responsible ...