Fernández Blanco, Álvaro (Date of defense: 2023-04-13)
Down syndrome (DS) is the most common genetic form of intellectual disability and arises from the partial or total trisomy of the Homo Sapiens Autosome 21. The cellular and molecular mechanisms that ...
D'Amico, Davide (Date of defense: 2013-11-22)
Estudios genéticos en pacientes sugieren que el gen del receptor tirosina quinasa de la neurotrofina de tipo 3 (NTRK3) podría contribuir en la patología del trastorno de pánico (PAND), un trastorno de ...
Catuara Solarz, Silvina (Date of defense: 2016-09-16)
This Thesis aims at addressing the therapeutic potential of a neuroplasticity-targeted treatment for intellectual disability (ID) in Down syndrome (DS). The therapy consisted of the administration of ...
Sierra Noguera, Cèsar (Date of defense: 2022-03-18)
The presence of an extra copy of Human Chromosome 21 (HSA21) in Down syndrome (DS) is one of the most complex genetic perturbations compatible with life and is the most common genetic cause of intellectual ...
Amador Arjona, Alejandro (Date of defense: 2008-07-23)
The correct development and function of CNS is critical for brain health of the organism. Early or chronic stress causes prominent alterations in brain function, and affects the expression of neurotrophic ...
Molas Casacuberta, Susanna (Date of defense: 2012-06-22)
The CHRNA5/A3/B4 genomic cluster encodes for the alpha5, alpha3 and beta4 subunits of the nicotinic acetylcholine receptors (nAChRs). Human genetic studies have revealed a significant association of ...
Xicota Vila, Laura (Date of defense: 2016-10-27)
Clinical trials seeking to improve cognitive performance are in dire need of biochemical biomarkers that reflect the processes taking place in the brain. In Down syndrome, this information is crucial ...
Quevedo Díaz, Marcos (Date of defense: 2017-12-21)
Understanding the neural basis of conscious perception is still one of the central unsolved problems in neuroscience. Current theoretical models of conscious processing include the Global Workspace ...
Espinosa-Carrasco, José (Date of defense: 2016-11-08)
New high-throughput behavioral systems enable the recording of continuous behavioral sequences with an unprecedented richness of signals and a deep temporal resolution. Automated systems offer neuroscience ...
Ortega Crespo, Mireia (Date of defense: 2018-01-23)
Down syndrome (DS) is the most frequent genetic cause of intellectual disability. It is a multifaceted condition characterized by impairments in cognition, communication, behavior and/or motor skills ...