Castells García, Àlvaro (Date of defense: 2019-07-01)
Chromatin organization and gene expression are interdependent. Previously, our group showed that nucleosomes form groups, termed clutches, whose size correlates with cell state. In this thesis, we ...
Theka, Ilda (Date of defense: 2017-02-06)
Las células madre embrionarias (ESCs) derivan de la masa cellular interna de los blastocistos y son capaces de generar las tres capas germinales. Muchos factores controlan la pluripotencia incluyendo ...
Pedone, Elisa (Date of defense: 2014-12-16)
Mouse embryonic stem (ES) cells derived from the inner cell mass of the blastocyst can be maintained in culture, under pluripotent conditions, using Serum+LIF medium. However, it has been published that ...
Aulicino, Francesco (Date of defense: 2016-12-15)
The adaptive response of cells to external stimuli is an intriguing mechanism at the basis of the existence of life itself. For this purpose, signalling pathways and gene regulatory networks elegantly ...
Pesaresi, Martina (Date of defense: 2019-11-25)
Retinopathies are a heterogeneous group of conditions that inevitably lead to vision incapacitation and blindness. Currently, they are incurable. Cell therapy has been proposed as a potential solution, ...
Sottile, Francesco (Date of defense: 2017-01-18)
Homotypic and heterotypic cell-cell fusion are key processes during development and tissue regeneration. On the other hand, aberrant heterotypic cell fusion between cancer and normal cells can contribute ...
Sebastián Perez, Rubén (Date of defense: 2021-09-10)
Chromocenters are established after the 2-cell (2C) stage during mouse embryonic development, but the factors that mediate chromocenter formation remain largely unknown. To identify regulators of 2C ...
Tu, Xiaochuan (Date of defense: 2023-07-27)
Embryonic stem cells (ESCs) are derived from the inner cell mass of the pre-implantation embryo and can recapitulate early developmental stages of the embryo. ESCs have the ability to continuously ...
Rodrigues Frade, João Manuel (Date of defense: 2017-01-20)
Fenómenos de fusión celular heterotípica están asociados con regeneración de tejidos en mamíferos. La reprogramación de células somáticas a estadios de células madre progenitora ...
Ricci, Maria Aurelia (Date of defense: 2015-06-05)
La arquitectura del genoma y la estructura de la cromatina, junto con los factores de transcripción son actores clave para la autorenovación, la pluripotencia y la diferenciación de las células madre ...