Fernández Blanco, Álvaro (Date of defense: 2023-04-13)
Down syndrome (DS) is the most common genetic form of intellectual disability and arises from the partial or total trisomy of the Homo Sapiens Autosome 21. The cellular and molecular mechanisms that ...
Catuara Solarz, Silvina (Date of defense: 2016-09-16)
This Thesis aims at addressing the therapeutic potential of a neuroplasticity-targeted treatment for intellectual disability (ID) in Down syndrome (DS). The therapy consisted of the administration of ...
Sierra Noguera, Cèsar (Date of defense: 2022-03-18)
The presence of an extra copy of Human Chromosome 21 (HSA21) in Down syndrome (DS) is one of the most complex genetic perturbations compatible with life and is the most common genetic cause of intellectual ...
Xicota Vila, Laura (Date of defense: 2016-10-27)
Clinical trials seeking to improve cognitive performance are in dire need of biochemical biomarkers that reflect the processes taking place in the brain. In Down syndrome, this information is crucial ...
Laguna Tuset, Ariadna (Date of defense: 2008-12-18)
El gen DYRK1A es troba situat en una regió del cromosoma 21 humà que s'ha associat a alteracions en el neurodesenvolupament. Aquest treball mostra com canvis en la dosis gènica de Dyrk1A en el ratolí ...
Alemany González, Maria (Date of defense: 2019-07-09)
Understanding the neural correlates of intellectual disability is still a central and unresolved problem in neuroscience. Here we have unravelled several candidate neural substrates of memory impairment ...
Pons Espinal, Meritxell (Date of defense: 2013-10-18)
Synaptic connections in the brain respond throughout their lives to the activity of incoming neurons, adjusting their biological properties to increment activity-dependent changes. Hippocampal neuronal ...