Aparicio i Prat, Estel (Date of defense: 2014-02-07)
Non-coding RNA functions are emerging in the recent years. In this thesis we describe a Natural Antisense Transcript (NAT) that controls the expression of LEF1 transcriptional factor. This LEF1 NAT ...
Batlle Gómez, Raquel (Date of defense: 2011-12-19)
The Snail1 transcriptional repressor is a key factor responsible in triggering epithelial to mesenchymal transition. Although Snail1 is widely expressed in early development, it is limited in adult ...
Millanes Romero, Alba (Date of defense: 2014-01-21)
Although heterochromatin is enriched with repressive traits, it is actively transcribed, giving rise to large amounts of non-coding RNAs. These transcripts are responsible for the formation and ...
Porta de la Riva, Montserrat (Date of defense: 2009-09-22)
La transició epiteli-mesènquima (TEM) és un procés en què cèl lules epitelials, immòbils i amb polaritat apico-basal transiten cap un fenotip mesenquimal o fibroblàstic. L'expressió del factor de ...
Cabrerizo Granados, David (Date of defense: 2020-11-30)
Snail1 is a transcriptional factor with a great relevance in tumor development as it is required for epithelial to mesenchymal transition and activation of cancer-associated fibroblasts (CAF). In this ...
Lambies Barjau, Guillem (Date of defense: 2019-01-10)
Cancer cells undergo epithelial-to-mesenchymal transition (EMT) to dissociate from the primary tumor and to survive to chemotherapy. EMT is controlled by Snail1, a transcriptional factor also required ...
Escrivà Izquierdo, María (Date of defense: 2008-06-20)
The product of the snail1 gene (SNAIL1) is a transcriptional repressor required for triggering the epithelial-to-mesenchymal transition (EMT). SNAIL1 transcription is induced when epithelial cells are ...
Alba Castellón, Lorena (Date of defense: 2016-02-17)
Snail transcription factor 1 triggers epithelial to mesenchymal transition. In cancer, this process provides tumoral epithelial cells with invasive characteristics. In this thesis, we demonstrated that ...
Iturbide Martínez de Albéniz, Ane (Date of defense: 2016-03-15)
Protein function is often regulated and controlled by posttranslational modifications, such as oxidation. Although oxidation has been mainly considered to be uncontrolled and nonenzymatic, many enzymatic ...
Gonzàlez Busqué, Núria (Date of defense: 2017-09-18)
Snail1 transcription factor is the key inducer of epithelial-to-mesenchymal transition (EMT). Here, we describe a novel role for Snail1 on the regulation of telomere integrity and transcription as well ...