Puig Tintó, Marta (Date of defense: 2023-05-02)
The exocyst is an heterooctameric protein complex that tethers secretory vesicles to the plasma membrane during exocytosis. Each exocytic event is mediated by 10-15 exocysts. However, how multiple ...
Balbastre Català, Borja (Date of defense: 2022-10-27)
Dual-specificity tyrosine-regulated kinases (DYRKs) are a conserved family of protein kinases present in all eukaryotes. In mammals, the association of DYRKs with a wide variety of putative substrates ...
Baltzis, Athanasios (Date of defense: 2023-03-20)
Recent advances in deep learning techniques have revolutionised protein structure modelling. Since AlphaFold2’s release, a set of tools have now become available to predict native-like structures at ...
Barrero Asencio, Mercedes (Date of defense: 2023-03-02)
During reprogramming of somatic cells into induced pluripotent stem cells (iPSCs), the epigenome needs to be reset. A prime example of this is the reversal of the silent state of the inactive X chromosome ...
Mansouri, Leila (Date of defense: 2023-03-27)
El continuo aumento de los proyectos de producción de datos genómicos a gran escala, como el "Earth BioGenome Project" (Lewin et al., 2018), pone los métodos de análisis de datos bajo una presión sin ...
Cianferoni, Damiano (Date of defense: 2023-10-09)
Aquesta tesi presenta diversos avenços que inclouen: (i) noves funcionalitats afegides a la “suite” d'eines de disseny de proteïnes FoldX per permetre als usuaris treballar amb qualsevol tipus de molècula; ...
Val Casals, Maria (Date of defense: 2020-07-09)
Els ritmes circadians són oscil·lacions diàries en paràmetres fisiològics necessaris per a què els organismes adaptin la seva activitat als cicles de llum i foscor. A nivell molecular, la maquinària ...
Pallarès-Masmitjà, Maria (Date of defense: 2022-12-19)
The need for efficient targeted integration of large DNA fragments in mammalian genomes is indisputable, although several nuclease-based technologies have been lately developed for small allele genome ...
Ivancic, Dimitrie (Date of defense: 2024-04-03)
Methods for genome engineering have enabled construction of synthetic genomes, therapeutically reprogrammed cells, synthetic organs, and modification of human genomes. Design and discovery of genome ...
Morales Pastor, Adrián (Date of defense: 2024-04-11)
G protein-coupled receptors (GPCRs) are central to cellular signaling and pivotal in drug development. This thesis investigates allosteric communication in GPCRs, crucial for their effective modulation ...