Di Vona, Chiara (Date of defense: 2013-09-20)
The view on how protein kinases regulate gene expression have recently expanded to include not only transcription factors but also histones, chromatin remodelers or components of the basal transcription ...
Fraile Beneitez, Rodrigo (Date of defense: 2021-07-23)
Eukaryotic DNA is condensed inside the nucleus, compacted into chromatin. The structure of chromatin is dynamic, and its accessibility to cellular machinery can be altered depending on the level of ...
Paulo Mirasol, Esther (Date of defense: 2014-12-19)
Reactive oxygen species (ROS) are a variety of molecules derived from molecular oxygen during different metabolic processes. ROS can react with different cellular components resulting in lipid peroxidation, ...
Iannone, Camilla (Date of defense: 2014-05-23)
Intron removal is a necessary step for expression of most genes in higher eukaryotes, and alternative splice selection is a highly regulated mechanism that endows a single gene with the possibility to ...
Martínez Cebrián, Gerard (Date of defense: 2019-12-03)
Upon environmental stresses such as temperature fluctuations or increases in osmolarity, yeast Saccharomyces cerevisiae induces a transcriptional reprograming in order to survive and adapt to the ...
Latorre Doménech, Pablo (Date of defense: 2021-06-15)
Virtually all living organisms are challenged by changes in their environment, such as sudden increases in osmolarity. To cope with these stresses, cells have developed stress responses that tune every ...
Barba Moreno, Laura (Date of defense: 2018-06-22)
DYRK1A (dual-specificity tyrosine-regulated kinase 1A) belongs to a conserved family of protein kinases present in all eukaryotes. DYRK1A is known to participate in cell proliferation and differentiation ...
Viéitez Manrique, Cristina (Date of defense: 2014-12-18)
In response to fluctuations in the environment, all living organisms have the ability to sense, respond and adapt to the new conditions. In budding yeast (Saccharomyces cerevisiae) there is a massive ...
Campos Mata, Leire de (Date of defense: 2019-12-18)
The highly conserved exonuclease Xrn1 plays a dual role in gene expression by degrading cellular mRNAs and promoting their transcription initiation and elongation. In this thesis we uncover an unanticipated ...