Molecular mechanism of PE5-induced cytotoxicity and generation of new cytotoxic nuclear-directed 

Vert Company, Anna (Date of defense: 2014-07-30)

Cytotoxic ribonucleases are promising agents to be used in the treatment of cancer. Our group previously described a cytotoxic human pancreatic ribonuclease variant, named PE5, which carries a nuclear localization signal. ...