Alsius Suñer, Mercè (Date of defense: 2012-09-28)
Chromosome abnormalities are one of the most important causes of congenital disorders. The main goal of this research is to give a broad view of the use and evolution of prenatal and postnatal cytogenetic ...
Callís i Figueres, Mariona (Date of defense: 2015-04-17)
El disseny i la producció de zimògens de ribonucleases que puguin ser específicament activats per la proteasa d’un patogen, constitueix un enginyós mecanisme per controlar la seva activitat enzimàtica ...
Mas de Xaxars Rivero, Teresa (Date of defense: 2012-10-02)
Colorectal Cancer is the main type of cancer in Spain. Up to 90% of the cases are sporadic in nature and its aetiology is still unclear. It is supposed to be a multi-factorial disease, where factors ...
Buján Murlà, Núria (Date of defense: 2016-01-29)
The diagnose of a mitochondrial disease implies biochemical studies such as the enzymatic activities of the mitochondrial respiratory chain (MRC) and the quantification of the amount of CoQ10 in energetic ...
Fàbrega Coll, Anna (Date of defense: 2012-07-20)
Mammalian spermatozoa acquire functionality during epididymal maturation and ability to penetrate and fertilize the oocyte during capacitation. Sperm quality results indicated that both epididymal ...
Oliveras Ferrarós, Cristina (Date of defense: 2013-06-21)
The aim of this doctoral thesis was to unravel mechanisms underlying primary resistance to trastuzumab regarding a putative new breast cancer subtype with mixed basal & ErbB2+ molecular features. Using ...
Carrion-Salip, Dolors (Date of defense: 2014-09-17)
Most current chemotherapeutic agents are of limited use due to their side effects and the resistance to treatment that tumour cells develop. In this thesis, we have contributed to the knowledge of these ...
Collado Gimbert, Rosa (Date of defense: 2019-11-11)
Bovine mastitis caused by Streptococcus uberis is a major problem in the dairy industry worldwide. Despite of that, there is no vaccine commercial available against it. Therefore, the objectives of this ...
Cufí González, Sílvia (Date of defense: 2015-05-22)
Aquest és el primer informe que demostra que l'autofàgia està mecànicament vinculat al manteniment de les cèl•lules tumorals que expressen alts nivells de CD44 i baixos nivells de CD24, que són típics ...
González Bártulos, Marta (Date of defense: 2017-03-17)
Nowadays, cancer is one of the leading causes of death in developed countries. Therefore, there is great interest of developing new therapeutic strategies to improve the efficiency of current cancer ...