Now showing items 21-40 of 1011

    Aïllament i caracterització funcional dels elements "Pax6" i "sineoculis" com a components de la xarxa gènica implicada en la regeneració dels ulls a planàries 

    Pineda i Tomàs, David (Date of defense: 2005-04-21)

    S'han identificat alguns dels presumptes components de la xarxa gènica implicada en la regeneració dels ulls a planària:<br/><br/>S'ha aïllat un fragment del gen de la opsina; <i>Gtops</i>. Aquest gen s'expressa als cossos ...

    Alteracions de la VIA RAS-RAF en càncer gastrointestinal amb defectes de reparació genòmica 

    Domingo Villanueva, Enric (Date of defense: 2007-02-27)

    La via Ras-Raf-MAPK regula funcions cel·lulars com la proliferació, la transformació o l'apoptosi. En càncer sol presentar mutacions activants en algun dels tres gens que codifiquen per a Ras (KRAS, HRAS y NRAS) i en un ...

    Alteracions del genoma i el transcriptoma en càncer colorectal. Aplicació a la recerca de factors de pronòstic. 

    Vendrell i Soler, Elisenda (Date of defense: 2005-04-07)

    El càncer colorectal és una malaltia genètica que afecta principalment als països desenvolupats. A les fases inicials del desenvolupament del tumor es formen adenomes benignes, que amb el temps poden adquirir una estructura ...

    Alteracions epigenètiques en càncer colorectal: Canvis globals i identificació de noves dianes. 

    Rodríguez Lumbiarres, Jairo (Date of defense: 2008-01-25)

    Tot i que la hipometilació global i regional del DNA va ser la primera alteració epigenètica detectada en tumors, les dificultats en el seu estudi, així com la manca de metodologies específiques que en permetin un anàlisi ...

    Alteracions epigenètiques en el càncer colorectoral 

    Frigola Mas, Jordi (Date of defense: 2005-07-01)

    Els dos principals objectius d'aquesta tesis són: (1) la realització d'un estudi global, (2) anàlisi i caracterització d'alteracions recurrents, en els canvis de metilació genòmica associats al càncer de còlon. Amb la ...

    Alternative mechanisms of gene regulation during hematopoiesis 

    Ullrich, Sebastian (Date of defense: 2018-12-19)

    Gene regulation orchestrates the development of different cell types and organs from the same genetic blueprint. While the basic mode of gene regulation is driven by transcription factors, there are a variety of other ...

    Alternative splicing control over naïve and primed pluripotency 

    Rodríguez Vaello, Victoria Eugenia (Date of defense: 2020-12-11)

    A fundamental step in embryo development is the transition through pluripotency. There are two known sequential states of pluripotency termed naïve and primed pluripotency. Considerable efforts have been made to characterize ...

    An analysis of taenidial fold formation via the study of Blimp-1 and pri 

    Ozturk Colak, Arzu (Date of defense: 2014-12-17)

    Examples of tubular organ systems like the mammalian lungs and vascular system abound in the animal kingdom. In this study we used the Drosophila melanogaster tracheal system to study tubular organ development. In particular, ...

    An Integrative approach to the systematics and evolution of some selected reptile groups from Arabia 

    Simó Riudalbas , Marc (Date of defense: 2018-07-20)

    Until relatively recently, many groups of terrestrial reptiles were considered to contain only few species vastly distributed across the Arabian Peninsula. This was mostly the result of the apparent morphological uniformity ...

    An Omics World: Colonization and Adaptive Processes of Styela plicata 

    Galià Camps, Carles (Date of defense: 2024-01-22)

    [eng] In the last decades biological invasions have emerged as a global concern, as they impact local biodiversity by disrupting ecosystem functioning and ultimately affect human health, economy and wellness. In a climate ...

    Analisis de la expresión y la función del gen beta-amyloid protein precursor like en relación a la vía de RasI en el disco imaginal de ojo de Drosophila melanogaster 

    Mora García, Natalia (Date of defense: 2012-10-26)

    Drosophila es un modelo versátil para entender las bases genéticas de la señalización celular. En particular, el ojo compuesto de Drosophila proporciona un tejido ideal para estudiar los mecanismos de integración de señales ...

    Analysis and coordination of different mechanisms controlling tube elongation during the development of the embryonic system in Drosophila melanogaster 

    Olivares Castiñeira, Ivette (Date of defense: 2017-12-20)

    The tracheal (respiratory) system of the Drosophila embryo is a network of interconnected epithelial tubes that supplies and exchanges the gas to maintain the homeostasis of the entire organism. Maintaining a controlled ...

    Analysis of co-ancestry links in modern and ancient human populations 

    Ferrando-Bernal, Manuel (Date of defense: 2021-07-09)

    The aim of this thesis is to apply Identity by Descent (IBD) methodology to identify ancestry connections among individuals from genetically similar populations. Recombination events diminish the likelihood to detect IBDs. ...

    Analysis of Drosophila buzzatii transposable elements 

    Rius Camps, Nuria (Date of defense: 2016-01-15)

    Los elementos transponibles son unidades genéticas capaces de insertarse en otras regiones de los genomas en los que habitan y están presentes en casi todas las especies eucariotas estudiadas. El interés del análisis de ...

    Analysis of genetic polymorphisms for statistical genomics: tools and applications 

    Morcillo Suárez, Carlos (Date of defense: 2011-12-19)

    New approaches are needed to manage and analyze the enormous quantity of biological data generated by modern technologies. Existing solutions are often fragmented and uncoordinated and, thus, they require considerable ...

    Analysis of genetic variation in microrna-mediated regulation and the susceptibility to anxiety disorders 

    Muiños Gimeno, Margarita (Date of defense: 2009-12-18)

    We have investigated genetic variation in microRNA-mediated regulation as a susceptibility factor for anxiety disorders following two different approaches. We first studied two isoforms of the candidate gene NTRK3 by ...

    Analysis of human genetic variation in candidate genes under positive selections on the human linage 

    Moreno Estrada, Andrés (Date of defense: 2009-04-21)

    Natural selection has played an important role in shaping human genetic variation, thus, finding variants that have been targeted by positive selection can provide insights about which genes influence human phenotypic ...

    Analysis of miRNA expression in Alzheimer’s disease. Potential use as early biomarkers 

    Siedlecki Wullich, Dolores J. (Date of defense: 2018-11-16)

    La Enfermedad de Alzheimer (EA) es un desorden neurodegenerativo caracterizado por la pérdida temprana de sinapsis seguida por una degeneración progresiva y déficits de memoria que derivan en demencia. A día de hoy, la EA ...

    Analysis of multiple protein sequence alignments and phylogenetic trees in the context of phylogenomics studies 

    Capella Gutiérrez, Salvador Jesús (Date of defense: 2012-11-16)

    Phylogenomics is a biological discipline which can be understood as the intersection of the fields of genomics and evolution. Its main focuses are the analyses of genomes through the evolutionary lens and the understanding ...

    Analysis of the contribution of linker histone H1 to the dynamics of RNA:DNA hybrids 

    Casas Lamesa, Anna (Date of defense: 2018-11-21)

    Histone H1 is a key determinant of higher-order chromatin structures and for a long time it has been considered a main transcriptional repressor. So consistent with its biochemical properties, the absence of histone H1 was ...