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Role and therapeutic potential of the endocannabinoid system in animal models of intellectual disability
Intellectual disability encompasses several neurodevelopmental disorders characterized by impairments in cognitive and adaptive functioning with onset during the developmental period. Currently, treatment of intellectual ...
A role for heterochromatin and repetitive elements in epigenetic inheritance
Gene regulation mechanisms control the level of transcription of each gene into RNA and the combination of expressed genes determines cell identity. Gene regulation is maintained by epigenetic mechanisms including DNA ...
A role for the glutamate system in modern human language and cognition
The human capacity for language is made up of various cognitive subcomponents, the convergence of which allows our species a unique ability to relay our thoughts. Identifying these subcomponents and establishing how they ...
The role of activated leukocyte cell adhesion molecule (ALCAM) in endometrial cancer progression and dissemination
El carcinoma endometrial (CE) es el tumor infiltrante más común del tracto genital femenino y el cuarto en la mujer en países desarrollados, siendo la tipología endometrioide (CEE) la más frecuente. El 80% de las pacientes ...
Role of ADAM17 in kidney disease: a clinical and experimental approach”
Les desintegrines i metal·loproteases (ADAMs) són una família de proteïnases que alliberen dominis proteics solubles en un procés conegut com a “shedding”. En concret, l’ADAM17 és el membre de la família millor estudiat. ...
Role of allyl esters in pest control
Les propietats insecticides d’una sèrie d’esters d’al•lil va ésser avaluada en diferents insectes mitjançant diferents modes d’aplicació. L’acció per aplicació tòpica va variar en funció de l’ester d’al•lil aplicat. El ...
Role of alpha 2,3-sialyltransferases ST3Gal III and ST3Gal IV in pancreatic ductal adenocarcinoma
Este trabajo demuestra que los genes que codifican para los enzimas beta-galactosido alfa-2,3-sialiltransferasa 3 (ST3Gal III), y en menor medida beta-galactosido alfa-2,3-sialiltransferasa 4 (ST3Gal IV), están directamente ...
The Role of alternative splicing in mammalian preimplantation development
The transition from maternal to embryonic control is a crucial time in an organism’s life cycle, with an overhaul of the epigenetic marks, targeted mRNA degradation and the initiation of transcription. Yet, not only do ...
Role of astrocytic IL-6 and IL-6R in normal physiology and neuroinflammation
La Interleucina 6 (IL-6) és una citocina altament multifuncional, amb moltes accions pleiotròpiques, considerada una de les principals citocines controlant el sistema immune i coordinant-lo amb els sistemes nerviós i ...
The role of behavioural and feedback mechanisms in mediating herbivory processes in Mediterranean seagrass ecosystems
The role of consumer-resource relationship is the basis of the structure and functioning of ecological communities. The traditional lens for studying such interactions have tended to omit the importance of the species ...
Role of bioactive food compounds in acute and chronic inflammation
En els últims anys, s’ha estudiat com els agents antiinflamatoris presents en els aliments poden modular la inflamació relacionada amb diverses malalties. Les procianidines presents en fruites i vegetals i els àcids grassos ...
The Role of blue spaces on health and well-being
The incorporation and regeneration of blue spaces in urban areas could promote health in cities. Nevertheless, research on the effects of these spaces is still scarce. This thesis aimed to evaluate the influence of blue ...
Role of brain-muscle circadian clock communication in skeletal muscle homeostasis and aging
Daily time-keeping of tissue functions promotes efficient organ function and systemic metabolic homeostasis, processes integral to life which are subject to decline with aging. To ensure the correct functional coordination ...
The role of brick-and-mortar stores in an omnichannel environment
Retail is changing as technology is growing. The traditional way of shopping has evolved thanks to mobile devices, and retailers are struggling to avoid customers’ attrition. Customers are immersed in a seamless omnichannel ...
Role of Capicua-L in RTK signaling and endocycle regulation
The HMG-box protein Capicua (Cic) is a conserved transcriptional repressor with key functions downstream of receptor tyrosine kinase (RTK)-Ras-MAPK signaling pathways. In both Drosophila and mammals, Cic is expressed as ...
Role of carnitine palmitoyltransferase 1A as a downstream effector of ghrelin in cortical neurons and hypothalamus
Previous studies have reported the importance of carnitine palmitoyltransferase (CPT) 1A as an essential part of downstream ghrelin signaling in the central nervous system (CNS) for the control of food intake. Lipid ...
The role of Caveolin-1 in the TGF-β-induced signalling in hepatocytes
The transforming growth factor-beta (TGF-β) is a cytokine involved in many physiological and pathological processes. Its dual role has been described in the liver, where it can either induce pro- or anti-apoptotic signals. ...
Role of CB2 cannabinoid receptor in nociception and food intake control
The endocannabinoid system is a natural modulatory system that participates in multiple physiological processes, including nociceptive, emotional and rewarding responses. These central responses are mainly mediated by ...
Role of CD44 in clear cell renal cell carcinoma invasiveness after antiangiogenic treatment
[eng] The arrival of antiangiogenic therapies represented a huge advance in the treatment of different tumors, such as renal carcinoma. However, despite initial good results, some tumors were able to develop different ...
The role of CDKN1B-p27kip1 deregulation in the pathogenesis of pediatric T-cell acute lymphoblastic leukemia
T-cell acute lymphoblastic leukemia (T-ALL) accounts for 10 15% of pediatric ALL. The oncogenic transformation of T-cell precursors is driven by a broad spectrum of genetic abnormalities. We have confirmed the high frequency ...
