Browsing by Title

Role of histone variant macroH2A and other chromatin regulators in genome regulation and response to drugs

Le Pannérer, Marguerite-Marie (Date of defense: 2022-01-21)

The relevance of epigenetics is increasingly recognized in haematopoietic diseases such as myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML). Variants of histones, such as macroH2As, and chromatin remodellers, ...

Role of HLA-G in shaping Natural Killer cell biology in cancer

Arroba Hidalgo, Ester (Date of defense: 2021-02-10)

The human leukocyte antigen-G (HLA-G) is a non-classic MHC class I molecule. It is called “non-classic” because it differs from classic MHC class I molecules due to its very low amount of polymorphism and highly tissue-restricted ...

Role of human polyomaviruses in lymphoproliferative disorders and bladder cancer

Robles Hellín, Claudia (Date of defense: 2014-07-07)

Polyomaviruses are suspected to cause cancer in humans although to date Merkel cell polyomavirus (MCPyV) is the only proven human carcinogen. Potential associations of up to nine polyomaviruses with 468 lymphoproliferative ...

Role of IL-10 and IL-6 overexpression in microglial cells during physiological aging: implications in phagocytosis and neurogenesis

Sánchez Molina, Paula (Date of defense: 2021-10-15)

L’envelliment és un procés fisiològic que afecta a tots els organismes vius. Al sistema nerviós central (SNC), aquest procés es caracteritza per neuroinflamació i deteriorament cognitiu, sent el principal factor de risc ...

Role of inflammation and oxidative stress in the systemic manifestations of chronic respiratory diseases: lung cancer, chronic obstructive pulmonary disease, and bronchiectasis

Qin, Liyun (Date of defense: 2022-07-14)

Introducció: Les malalties respiratòries cròniques com el càncer de pulmó (CP), la malaltia pulmonar obstructiva crònica (MPOC) i les bronquiectàsies afecten tant les estructures pulmonars com els òrgans fora del sistema ...

The role of information and telecommunication technologies in the productivity of Central and Eastern European countries

Skorupinska, Aleksandra Aldona (Date of defense: 2017-09-28)

La tesi està escrita com un manuscrit de cinc publicacions científiques i presenta una de les primeres evidències de la relació entre les tecnologies de la informació i la comunicació (TIC) i la productivitat en els països ...

Role of Interstitial Cells of Cajal in the Pacemaker Activity and Neurotransmission in the Rat Colon

Albertí i Martínez de Velasco, Elena (Date of defense: 2005-01-25)

Els objectius d'aquesta tesi han estat l'estudi de la funció de les cèl·lules intersticials de Cajal (ICCs) en l'activitat marcapassos i en la transmissió neuromuscular, dins el tracte gastrointestinal. L'estudi s'ha ...

Role of intra-abdominal hypertension in the development and outcome of ovarian hyperstimulation syndrome

Petrenko, Aleksei (Date of defense: 2022-09-21)

[spa] INTRODUCCIÓN: El síndrome de hiperestimulación ovárica (SHO) es la complicación yatrogénica más grave y potencialmente mortal asociada con las técnicas de reproducción asistida (TRA). El SHO moderado o grave puede ...

The Role of intracellular amyloid β-peptide in the pathophysiology of GNE myopathy and Alzheimer's disease

Bosch Morató, Mònica (Date of defense: 2015-07-17)

The Amyloid β-peptide (Aβ) is accumulated in several diseases including GNE myopathy and Alzheimer’s disease (AD). GNE myopathy is a skeletal muscle disorder caused by biallelic mutations in the UDP-N-acetylglucosamine ...

Role of iron content and endostatin expression in the progression of diabetic retinopathy

Bonet Arribas, Aina (Date of defense: 2022-06-17)

La retinopatia diabètica és la principal causa de ceguera en la població adulta i s’espera que la seva prevalença continuï augmentant en els propers anys. Està dividida en una fase no proliferativa, en la que es donen ...

Role of KCN E4 on the voltage gated potassium channel Kv1.3 = Paper de KCNE4 en el canal de potassi dependent de voltage Kv1.3

Solé i Codina, Laura (Date of defense: 2013-12-13)

Voltage gated potassium channels (Kv) play important roles in different biological process such as generation and propagation of the nerve pulse and the cardiac action potential, promotion of insulin secretion, cell volume ...

Role of kinase DYRK1A in the neurogenesis of the embryonic telencephalon

Trujillano Fernández, Alejandro (Date of defense: 2024-02-08)

[eng] DYRK1A is a kinase that is expressed in virtually all tissues and cell types and is implicated in human diseases. Several studies indicate that DYRK1A is a dose-dependent gene with a prevalent function in brain ...

The Role of Kindlin-2 in the progression of renal fibrosis

Jan, Budour H. (Date of defense: 2017-12-15)

Chronic kidney disease (CKD) is usually characterized by histological lesions of glomerulosclerosis and tubulointerstitial fibrosis (TIF). The progressive TIF is mediated by multiple mediators such as growth factors, ...

The role of landscape and species attributes in insect community assembly, population genetics and plant-insect interactions in expanding Quercus ilex forests

Ruiz Carbayo, Helena (Date of defense: 2018-05-29)

Los mecanismos responsables de la colonización y coexistencia de las especies en los hábitats, es uno de los mayores rompecabezas en ecología de comunidades. Varias teorías, entre ellas la teoría de nicho, neutral y de ...