Universitat de Barcelona
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Kv1.3 plays a crucial role in leukocytes, where it regulates activation and proliferation. In these cells, Kv1.3 is coexpressed with modulatory subunit KCNE4. This ancillary peptide acts as a dominant negative regulator ...
[spa] La expresión genética es un proceso celular clave, que además está relacionado con la susceptibilidad genética a enfermedades y rasgos complejos. La mayoría de genes se someten a splicing alternativo (AS). Las variantes ...
Metallothioneins (MTs) are a superfamily of ubiquitous and small cysteine rich metalloproteins present in all eukaryotes and some prokaryotes organisms, that exhibit preferences to coordinate divalent or monovalent heavy ...
INTRODUCTION: For decades it was known that many species contain embryo specific linker histone H1 variants that replace the somatic H1 during early embryogenesis. This is especially important because the early embryo ...
Epigenetic factors, such as histone post-translational modifications and DNA methylation, are critical determinants of gene expression, which ultimately defines cell identity and function. Despite intense research in DNA ...
During the process of corticogenesis, cortical radial glial cells (RGs) generate sequentially most of the distinct types of neurons and glial cells that will populate the neocortex. The generation of these cells at the ...
LIF is a pleiotropic cytokine that can act as an immunomodulatory factor in different biological processes, such as embryo implantation, organ transplantation tolerance and multiple sclerosis. Here, we have observed that ...
Glucocorticoids are frequently included in the chemotherapy regimens administered to patients with CLL because they are potent immunosuppressant agents and because they are able to induce apoptosis in CLL cells. Although ...
The pro-apoptotic effects of two new drugs have been studied for the development of new strategies for cancer treatment. On the one hand, we proved that AICAR induces apoptosis in an AMPK- and p53-independent manner in ...
The development of high-throughput sequencing technologies has prompted the evaluation of large cohorts of different tumor types. The results from these comprehensive genomic studies have revealed the most commonly mutated ...
[cat] El glioblastoma (GBM) és el tumor primari cerebral més freqüent i més agressiu. Els pacients amb GBM tenen una supervivència mitjana de 15 mesos. Una dels principals dificultats que presenten els GBMs per ser tractats ...
We propose a molecular description of the mechanism whereby the osteogenic master gene Osx is controlled post-transcriptionally through a mechanism driven by miR-322/Tob2, strongly suggesting that control of specific mRNA ...
Glioblastoma (GBM) is the most frequent and malignant primary brain tumor. The current standard of care for adult patient with diagnosed GBM is surgery followed by radiotherapy (RT) plus concomitant and adjuvant temozolomide ...
Enzymes are the most proficient catalysts that evolution has developed to assist the chemical reactions that make life possible. By means of molecular simulations the present thesis addresses three aspects of fundamental ...
In marine teleosts that spawn pelagic eggs (pelagophils), the process of oocyte hydration that occurs during meiosis resumption is a key physiological process for the survival of the eggs in the ocean. Previous studies ...
Efficient discovery of bioactive molecules is an essential goal of Computer-Aided Drug Design (CADD). The molecules can be used as chemical probes, to validate novel targets, or as starting points for drug discovery. ...
In the present thesis we have explored different factors that impede accurate quantitative description of non-covalent protein-protein and protein-ligand interactions and design of new potent and specific binders from the ...
Budding yeast (Saccharomyces cerevisiae) cells coordinate cell growth and cell cycle progression essentially during G1, where they must reach a critical cell size to traverse Start and enter the cell cycle. The most upstream ...
[eng] This thesis addresses molecular segregation in perylene-based systems, including lyotropic chromonic liquid crystals and water-in-water emulsions. These systems offer several advantages compared to conventional ...
In this thesis, the phase behavior in water of a technical grade diglycerol-based surfactant (C41V) and a group of dyes (Quinaldine Red, Pyronin Y, N-Alkylthiacarbocyanines, Oxacarbocyanines, Pinacyanol and Alcian Blue) ...
