Browsing Universitat de Barcelona by Title

Synthesis of 2-Vinyl sphingolipids as S1PL inhibitors

Calderón i Almendro, Raquel (Date of defense: 2017-03-14)

Sphingolipids (SLs) are components of eukaryotic cell membranes that in the last 30 years have shown not only a structural role but also be involved in signaling processes and cellular responses. Therefore, the development ...

Synthesis of biaryl bicyclic peptides for recognition of protein surfaces

Garcia Pindado, Júlia (Date of defense: 2017-05-12)

The present thesis is based on the development and optimization of a solid-phase strategy to prepare biaryl bicyclic pentapeptides. Suzuki-Miyaura cross-coupling reactions were used to obtain the biaryl bridge. The metholodogy ...

Synthesis of C10‐C16 linear symmetrical ethers from n‐alcohols over heterogeneous acid catalysts

Casas Fernández, Carlos (Date of defense: 2013-12-13)

Combustion of diesel fuel in a diesel engine is a complex process where several pollutants are emitted in the engine exhausts. To solve this problem and at the same time accomplish with the increasingly stringent regulations ...

Synthesis of ethers as oxygenated additives for the gasoline pool

Badia i Córcoles, Jordi Hug (Date of defense: 2016-11-07)

Functionalized ion-exchange resins are polymer-based materials that can be used as catalysts, in a wide variety of chemical reactions, to achieve highly selective formation of desired products at cost-effective rates. Among ...

Synthesis of Highly Structured and Receptor-Selective Tetradecapeptidic Analogs of Somatostatin: Fine-tuning the non-covalent interactions among their aromatic residues

Martín-Gago, Pablo (Date of defense: 2013-10-11)

Somatostatin, a peptidic hormone also known as somatotropin release-inhibiting factor (SRIF), is implicated in multiple biological functions, mediated by direct interaction of the peptide with a family of structurally ...

Synthesis of new heteropolycyclic compounds with potential antitumor activity = Preparació de nous compostos fenólics i derivats amb potencial activitat antitumoral

Soucek, Richard (Date of defense: 2014-01-28)

The study deals with the synthesis and biological activity of 4 different antitumours: Tetrahydro-[1,4]-dioxanisoquinolines, combretastatin A-4, dioxancarbazoles and resveratrol analogues. This study describes the synthesis ...

Synthesis of nitrogenated compounds with potential interest for the treatment of Unmet Medical Needs

Bagán Polonio, Andrea (Date of defense: 2022-09-23)

The synthesis of heterocyclic organic compounds allows access to a wide arsenal of compounds with potential pharmacological activity. This Thesis is part of the field of pharmaceutical chemistry, developing new therapeutic ...

Synthesis of polycyclic compounds with antiviral activity

Torres Costa, Eva (Date of defense: 2013-09-30)

Research for new antivirals to treat Influenza A virus infections has gained importance during this last decade due to the imminent danger of an Influenza pandemic. For some years, several new strains of this virus have ...

Synthesis of Sonic Hedgehog protein and development of peptide binders using phage display libraries

Palà Pujadas, Judith (Date of defense: 2018-03-12)

Chemical protein synthesis has become a potent tool for the synthesis of proteins, especially those which are not easily accessed by DNA recombinant methods, such as proteins with posttranslational modifications. The key ...

Synthesis of TGF-Beta inhibitors and compounds for spatiotemporal drug release

Byrom, Daniel (Date of defense: 2018-11-23)

During this doctoral thesis, we have synthesised hundreds of grams of the TGF-β inhibitor LY2157299 (Galunisertib). This product was used by the group of Eduard Batlle in their investigations into the roles that TGF-β plays ...

Synthesis, Biological Evaluation and Insights into the Mode of Action of Quinoxaline Containing Peptides

Zamudio Vázquez, Rubí (Date of defense: 2014-02-14)

Triostins are members of the quinoxaline antibiotic family, together with the "prototypical bisintercalator" echinomycin. These molecules display interesting antitumour activities as they inhibit transcription through ...

Synthesis, Characterization and Deposition on Surfaces of Curcuminoids-based Systems

Díaz Torres, Raúl (Date of defense: 2018-07-20)

Nanoscience and Nanotechnology have become research areas that promote the design and fabrication of novel devices with a number of different applications with the aim of satisfying the growing demand of the society regarding ...

Synthesis, structural elucidation and biological evaluation of Pipecolidepsin A and Phakellistatin 19

Pelay Gimeno, Marta (Date of defense: 2013-02-15)

Pipecolidepsin A is a cyclodepsipeptide produced by a Homophymia marine sponge that has shown interesting anticancer properties against several human cancer cell lines. From a structural point of view, it is a “head-to-side-chain” ...

Synthetic approaches towards organic products of pharmaceutical interest

Jora, Beatrice Elena (Date of defense: 2022-10-27)

[eng] The present thesis focuses on the study and synthesis of three active principles (APIs) with therapeutic activity. Although these compounds are commercially available, their route of synthesis are very old, therefore ...

Synthetic engineering of membrane transport to increase photosynthesis and water use efficiency = Enginyeria sintètica del transport de membrana per tal d’augmentar la fotosíntesi i l’eficiència en l’ús de l’aigua

Minguet Parramona, Carla (Date of defense: 2015-12-11)

The rapid increase on world’s population is threatening food security, mainly in developing countries, where poverty and hunger are already a big concern. However, a growth in agriculture generates an overall economic ...

Synthetic Polymyxin-based Peptides Against Multidrug Resistant Bacteria: A Therapeutic Option

Rudilla Mateo, Héctor (Date of defense: 2019-01-18)

Pseudomonas aeruginosa and Staphylococcus aureus are nosocomial opportunistic pathogens causing a wide variety of both acute and chronic infections, such as pneumonia, bacteraemia, and urinary tract infections. Immunocompromised ...

System building : estudio etnográfico de los proyectos de investigación de la School of Computer Science de Carnegie Mellon University, un "computer-intensive campus" norteamericano

Serra Hurtado, Arturo (Date of defense: 1992-01-01)

Esta tesis consiste en una etnografía de la cultura informática de investigación de la Carnegie Mellon University, desarrollada mediante un trabajo de campo de dos años en la School of Computer Science de dicha universidad ...

A systematic and comprehensive approach for large-scale genome-wide association studies. Unraveling non-additive inheritance models in age-related diseases

Guindo Martínez, Marta (Date of defense: 2019-12-18)

Genome-wide association studies (GWAS) have been proven useful for identifying thousands of associations between genetic variants and human complex diseases and traits. However, the identified loci account for a small ...

Systematic characterization of the genome-wide and nuclear distribution of six linker histone H1 variants in human cancer cells

Salinas Pena, Mónica (Date of defense: 2023-09-20)

[eng] The histone H1 family comprises up to seven members in human somatic cells. However, H1 studies have been limited by the lack of specific ChIP-grade antibodies. Here, we have mapped six endogenous H1 variants in T47D ...

Systematic identification and quantification of substrate specificity determinants in human protein kinases = Identificación y cuantificación sistemática de determinantes de la especificidad por sustrato en las proteínas quinasas de humano

Alonso Tarajano, Manuel Alejandro (Date of defense: 2013-10-24)

In human there are 518 protein kinases reported and many of them are involved in several cellular processes and also in important pathologies. Kinases have a diverse specificity for the sequences they phosphorylate, and ...