Mostrando ítems 8153-8172 de 11170
Motos Galera, Ana (Fecha de defensa: 2022-12-21)
[eng] INTRODUCTION: Nosocomial pneumonia caused by Pseudomonas aeruginosa is associated with high mortality and morbidity. Furthermore, the high incidence of multi-resistance to antimicrobials makes both empirical and ...
Segovia Laserna, Rosario (Fecha de defensa: 2022-03-08)
After decades of exorbitant antibiotic misuse and overuse in human medicine, agriculture and livestock industry, multidrug resistant bacteria (MDR) have become a major medical concern. In this regard, the design of new, ...
Grañé Boladeras, Natàlia (Fecha de defensa: 2012-12-21)
hENT2 is the human nucleoside transporter for which most splice variants have been described to date, in contrast to hENT1 for which no variants have been reported yet. In this dissertation, we have identified 3 novel ...
Sola Lao, Irene (Fecha de defensa: 2016-11-15)
This PhD Thesis pursues the development of novel anti-Alzheimer and antiprotozoal drug candidates upon exploitation of three different novel approaches: Multitarget therapies, Drug repurposing, and Validation of a novel ...
Gandioso Ubieto, Albert (Fecha de defensa: 2018-11-12)
In the present Thesis, it has been carried out the development of new chemical tools for the diagnosis and treatment of cancer through the use of light as an external factor. On the one hand, light can be used to control, ...
Postma, Tobias Maria (Fecha de defensa: 2014-03-21)
Cysteine (Cys) is a unique amino acid due to its ability to form reversible covalent disulfide bonds. These bonds cause conformational constraints which make peptides or proteins more rigid and stable. In addition, the ...
Fabregas Vallvé, Norma (Fecha de defensa: 2013-09-20)
The general objective of this PhD thesis is to investigate the mechanistic bases for plant hormones Brassinosteroids (BRs) action in plant vascular development. To this end, we have used a multidisciplinary approach by ...
Lluscà Jané, Marta (Fecha de defensa: 2015-07-10)
The objective of this work was to study two different light management approaches to enhance the efficiency of thin film Si solar cells and these were the manipulation of the light path (light trapping) and changing the ...
Infanzón Ramos, Belén (Fecha de defensa: 2017-09-15)
This thesis is focused in the identification and improvement of lipases for biotechnological application. The importance of lipases is increasing in several industries. However, the commercial use of lipases is still a ...
Sallaberry Pinto, Júlia (Fecha de defensa: 2019-03-22)
Local invasion is a key cell-biological event in the metastatic cascade. In response to a changing microenvironment, cancer cells may act using two main strategies of invasion: single cell invasion and collective invasion. ...
Legnaioli, Tommaso (Fecha de defensa: 2013-02-26)
The increase in water use efficiency in order to maintain or improve crop yields in times of global warming and progressive reduction of water resources is one of the major challenges faced by agricultural sciences in the ...
Brun Cubero, Omar (Fecha de defensa: 2016-07-27)
An alternative allowing diene-derivatised polyamides to be used in Diels-Alder conjugation reactions has been explored and developed. In this methodology, conjugation takes place between a fully protected, resin-linked ...
Andrés Benito, Pol (Fecha de defensa: 2019-12-17)
Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are clinically distinct neurodegenerative diseases that are connected by genetic and pathological overlap. ALS patients present with muscle ...
Pérez Areales, Francisco Javier (Fecha de defensa: 2017-07-14)
Alzheimer’s disease (AD) is the main neurodegenerative disorder and one of the most important health-care problems worldwide, because of its high prevalence and personal and economic impact. To aggravate this situation, ...
Perramón Corominas, Meritxell (Fecha de defensa: 2022-10-17)
[eng] Chronic liver diseases are one of the most prevalent diseases worldwide. The study of the signaling pathways involved in the fibrogenic process as well as the evaluation of novel therapies such as nanoparticles (NPs) ...
Khaled Elazab, Abdelhalim (Fecha de defensa: 2015-07-13)
Cereals are the basis of the normal diet in most Mediterranean countries and it is estimated that they account for 35-50% of the regional populations’ dietary energy consumption. Water deficit is the main constraint limiting ...
Botteri, Gaia (Fecha de defensa: 2018-03-14)
Diabetes represents one of the biggest health challenges of the 21st century. Insulin resistance is the primary defect in the most common form of diabetes, type 2 diabetes mellitus (T2D), and is defined as a failure in the ...
Zarzuela Fernández, Ricardo (Fecha de defensa: 2014-11-27)
The aim of this thesis was to study quantum phenomena and excitation modes in type-I superconductors and magnetic vortices. The intermediate state in type-I superconductors is characterized by the gradual penetration ...
Vargas Nadal, Guillem (Fecha de defensa: 2020-10-23)
Quatsomes are lipid-based nanovesicles developed by Nanomol group, composed of ionic surfactants and sterol derivatives. Regarding their properties, Quatsomes have shown to be highly homogenous and stable for years, important ...
Yefimenko Nosova, Natalia (Fecha de defensa: 2016-06-17)
AMPA receptors (AMPARs) are responsible for the 90% of synaptic transmission and are involved in plasticity, developmental and neurological processes. Their function depends on the proteins interacting with the AMPAR ...