Now showing items 9643-9662 of 11159

    Role of PI3K in pericytes during angiogenesis 

    Figueiredo, Ana Raquel Martins (Date of defense: 2017-06-09)

    Pericytes (PCs) are important regulators of the vascular development promoting vessel growth and stabilization. They have recently emerged as a therapeutic target to promote or inhibit angiogenesis. Therefore, advancing ...

    Role of polyreactive autoantibodies in the physiopathology of Sjögren’s Syndrome 

    Gutiérrez Cózar, Rebeca (Date of defense: 2024-01-22)

    [eng] Sjögren's syndrome (SjS) is a chronic autoimmune disease that mainly affects the exocrine glands and is characterized by the presence of antinuclear antibodies such as anti-Ro52 and anti-dsDNA. Our previous analysis ...

    Role of Reelin in synaptogenesis and synaptic stabilization in the adult brain 

    Bosch Piñol, Carles (Date of defense: 2014-09-25)

    Reelin is a high molecular weight extracellular glycoprotein that exhibits key roles both in the development of the central nervous system and in adult synaptic plasticity. Reelin expression during brain development ...

    The role of responsible innovation in increasing firm performance in small and medium-sized enterprises and increasing their sustainability 

    Gonzales Gemio, Carla Tattiana (Date of defense: 2021-03-22)

    It is difficult to imagine life without changes influenced by technology and innovation, which are characteristic of the era in which we live, with changes that, albeit always present throughout the history of mankind, are ...

    The role of RIPK1 in TNF-induced cell death in intestinal epithelial cells 

    Garcia Carbonell, Ricard (Date of defense: 2017-12-22)

    Inflammatory bowel diseases (IBD) are chronic inflammatory processes that affect the gastrointestinal tract. IBD is characterized by an intestinal inflammation and epithelial cell injury leading to a poor psychosocial ...

    Role of SIRT6 in Chromatin 

    Santos Barriopedro, Irene (Date of defense: 2015-05-08)

    Chromatin compaction is regulated by different factors, among them histone posttranslational modifications. There are different histone modifications, and among them, acetylation and methylation of lysine residues. Acetylation ...

    The role of social capital on information and communication technology usage in SME´s of Catalonia 

    Polo Herrera, Julio Cesar (Date of defense: 2021-09-13)

    Hoy en día es difícil imaginar nuestra vida sin las Tecnologías de la Información (TI), de hecho, las Tecnologías de Información y Comunicación (TIC) juegan un papel muy importante en casi todas las organizaciones públicas ...

    The role of species niche, species dispersal and landscape factors in the assembly of novel woody communities in metropolitan Mediterranean regions 

    Gamboa Badilla, Nancy (Date of defense: 2017-12-19)

    Biological diversity in a global scale has been threaten seriously by anthropogenic disturbances in ecosystems. Changes in land cover and land use affect biodiversity, causing habitat loss and species extinction, or ...

    Role of substrate attachment in cell mechanics: Implications in neutrophils and microvascular endothelial cells. 

    Roca-Cusachs Soulere, Pere (Date of defense: 2007-02-15)

    EN CATALÀ DE LA TESI DOCTORAL<br/><br/>"Importància de l'adhesió al substrat en la mecànica cel·lular: Implicacions en neutròfils i cèl·lules endotelials microvasculars".<br/><br/>En organismes multicel·lulars complexos ...

    Role of TGFβ family members on physiological angiogenesis and ovarian cancer 

    Alsina Sanchís, Elisenda (Date of defense: 2016-01-21)

    Role of TGFβ in physiological angiogenesis and ovarian cancer Transforming Growth Factor Beta (TGFβ) is a signalling pathway involved in a wide range of cellular processes such as proliferation, differentiation, angiogenesis, ...

    Role of the atypical CDK activator RINGO beyond meiosis 

    González Pérez, Laura (Date of defense: 2019-12-12)

    The cell cycle is orchestrated by the periodic activation of Cyclin-dependent kinases (CDKs). The enzymatic activity of CDKs depends on their association with cyclins, however, in some cases these kinases can be activated ...

    The role of the G-protein coupled receptor 120 (GPR120) on the FGF21 system in white and brown adipose tissues 

    Quesada López, Tania Paloma (Date of defense: 2018-07-09)

    Obesity prevalence has tripled in the last fifty years. For this reason, it is considered the pandemic of the century. It is characterized by the accumulation of metabolic abnormalities triggered by an increase in the size ...

    Role of the Hippo pathway in planarians 

    Sousa, Nidia de (Date of defense: 2017-07-17)

    A successful cell renewal, which occurs throughout the life of an organism, relies on multiple events, including proliferation and differentiation of progenitor cell populations, and death of unnecessary cells. Out of the ...

    Role of the histone demethylase PHF2 during early neurogenesis 

    Pappa, Stella (Date of defense: 2019-04-10)

    During neural development, signaling molecules and networks of expressed transcription factors cooperate to control cellular fate. Chromatin acting factors are essential players in cell proliferation and differentiation ...

    The role of the histone variant macroH2A in the regulation of chromatin architecture 

    Corujo Garcia, David (Date of defense: 2019-12-10)

    In the eukaryotic cell nucleus, DNA is tightly wrapped around histone complexes, forming a dynamic structure known as chromatin. The nucleosome particle is the basic repeating unit of the chromatin fiber and its protein ...

    Role of the human Concentrative Nucleoside Transporter 1 (hCNT1) in oncogenesis 

    Banjer, Hamsa Jameel (Date of defense: 2018-07-06)

    Transportome alterations have been associated with oncogenesis. The loss of human Concentrative Nucleoside Transporter 1 (hCNT1) during carcinogenesis seems to be a relatively common event in tumors and might by itself ...

    Role Of The Innate Immunity In The Etiopathogenesis of Primary Sjögren Syndrome: Influence Of Viral And Immunogenetic Factors Related To Cell Adhesion Molecules In Systemic Disease And Autoantibody Profile 

    Gheitasi, Hoda (Date of defense: 2024-01-26)

    [eng] Sjögren Syndrome is a systemic autoimmune disease that affects the exocrine glands, most notably the salivary and lacrimal glands, although it can affect other mucosal surfaces. Inflammation at these sites leads to ...

    Role of the Kinases NEK6, NEK7 and NEK9 in the Regulation of the Centrosome Cycle 

    Sdelci, Sara (Date of defense: 2012-12-13)

    This thesis project is focused on the study of the signaling module formed by the NIMA-related protein Nek6, Nek7, and Nek9 and their function during early mitosis, with particular interest in centrosome separation and ...

    Role of the NADPH oxidase NOX4 in hepatocyte proliferation 

    Herranz Itúrbide, Macarena (Date of defense: 2021-09-23)

    [spa] La familia de las NADPH oxidasas ha emergido en los últimos años como una importante fuente de producción de radicales libres de oxígeno (ROS), los cuáles juegan un papel fundamental en situaciones fisiológicas y ...

    Role of the NADPH Oxidase NOX4 in Liver Fibrosis and Hepatocarcinogenesis 

    Crosas Molist, Eva (Date of defense: 2015-02-09)

    Reactive oxygen species (ROS) are short-lived, highly electrophilic molecules generated by the partial reduction of oxygen to form superoxide, hydrogen peroxide and hydroxyl radical as well as other secondary metabolites. ...