Universitat de Barcelona
Now showing items 10205-10224 of 11042
To achieve malaria elimination, great emphasis must be put on targeting the parasite’s transmissible stages, so that along with effective treatment of clinical malaria caused by asexual stages, complete interruption of the ...
Cancer is characterised by the lost of physiological control and the malignant transformation of cells that acquire functional and genetic abnormalities, leading to tumour development and progression. Colon and lung cancer ...
[spa] La reprogramación metabólica es uno de los procesos que caracterizan el cancer. Estos cambios en el metabolismo de las células tumorales no solo permiten a las células obtener los metabolitos necesarios para su ...
Non-canonical activation of p38α MAPK has been associated to cardiomyocyte death in several cardiovascular pathologies, such as myocardial ischaemia-reper- fusion injury. Unfortunately, current p38α inhibitors are mainly ...
The aim of this work is to develop an effective new MGA delivery system by means of nanotechnology for the treatment of leishmaniosis which could be administered by parenteral or oral route in a future. Moreover, for ...
[eng] Malaria caused 241 million cases and 627,000 deaths worldwide in 2020, representing one of the biggest threats for global health nowadays. The currently available arsenal of antimalarial drugs is insufficient to ...
La malaria es una enfermedad infecciosa producida por Plasmodium, protozoo transmitido a través de la picadura de mosquitos del género Anopheles. Aunque existen tratamientos y medidas de prevención, en los países tropicales ...
In this thesis we have focused on two novel therapeutic strategies that target the crosstalk between the tumor cells and the microenvironment. Chronic lymphocytic leukemia (CLL) remains an incurable disease where high ...
[eng] Drug discovery is the process by which new drugs are found and developed into the market. Given the scope of this thesis, the term “drug” will refer to small molecules and the term “target” to proteins, otherwise ...
The identification of imidazoline receptors (IR) as a novel class of receptors has posed manifold research questions regarding their pharmacological and potential therapeutic properties. Among them, I2-IR receptors are ...
Colorectal cancer (CRC) is the second-highest cause for cancer-related mortality worldwide. Patients suffering from CRC generally don’t die from primary tumours but rather from metastasis, for which there are no effective ...
The tumor microenvironment (TME) is gaining momentum due to its contribution to cancer progression and therapy resistance. This TME has a direct crosstalk with tumor cells that involves the activation of different ...
This study explores the impact of manipulating Task Complexity simultaneously along both pre-task planning time and the degree of displaced, past time reference on L2 narrative oral production. By drawing on consolidated ...
Drawing on known language learning processes, principles behind language course syllabus design, and previous second language acquisition research, Long introduced the concept of task-based language teaching (TBLT) in 1985. ...
[eng] Second language (L2) pronunciation learning in foreign language instructional contexts is particularly challenging due to insufficient quantity and quality of L2 input. Decades of L2 speech acquisition research have ...
One of the major areas of interest in task-based language learning and teaching (TBLT) has been the psycholinguistically-oriented strand, which explores the way in which task design may interact with second language (L2) ...
ABREVIADO:<br/><br/>La tesis se divide en dos aspectos complementarios: el trabajo filológico y el comentario histórico científico. <br/>El trabajo filológico ha consistido en la edición crítica de cuatro textos de autores ...
Por el nacimiento y habitual radicación en las Islas Baleares, y en tanto cursamos los estudios preuniversitarios. permitió que durante varios años llamara poderosamente nuestra atención el observar en innumerables ...
Se han sintetizado una nueva familia de moléculas, puramente orgánicas y con número par de electrones, que presentan propiedades paramagnéticas. El trabajo de esta tesis ha consistido en conocer el fundamento por el cual ...
This thesis analyses the Spanish tax system between 1960 and 1990, with special attention to the developments in progressivity, redistribution and inequality. It addresses the reforms that took place during the transition ...
