Changes in codon-pair bias of human immunodeficiency virus type 1 have profound effects on virus replication in cell culture 

    Martrus Zapater, Gloria (Date of defense: 2013-07-10)

    Human immunodeficiency virus type 1 (HIV-1) has a biased nucleotide composition different from human genes. This raises the question of how evolution has chosen the nucleotide sequence HIV-1 observed today, or to what ...