Vegliante, Maria Carmela (Date of defense: 2013-09-26)
Mantle cell lymphoma (MCL) is an aggressive subtype of non-Hodgkin lymphomas associated with poor prognosis and frequent relapses. Recently, the neuronal transcription factor SOX11 has been identified ...
Di Pietro, Ornella (Date of defense: 2015-11-06)
The aim of this PhD thesis consists of the synergistic combination of both highly efficient synthetic approaches and molecular modelling tools for the structure-based drug design and synthesis of novel ...
Padrão, Gonçalo (Date of defense: 2014-10-24)
To err is certainly human. Detect and correct our errors are fundamental during our interaction with the outside world. Therefore, understanding the nature of the brain mechanisms involved in the ...
Martínez Quetglas, Iris (Date of defense: 2018-01-09)
Insulin-like growth factor (IGF) signaling is frequently altered in HCC, including activation of IGF1R, IGF2 overexpression, IGFBP3 downregulation and IGF2R allelic losses1,2. A previous study from our ...
Requena-Méndez, Ana (Date of defense: 2016-03-29)
BACKGROUND For drug-compliant patients, poor responses to tuberculosis (TB) treatment might be attributable to subtherapeutic drug concentrations. An impaired absorption of rifampin and isoniazid was ...
Braga Pereira, Joana (Date of defense: 2012-07-20)
Parkinson’s disease (PD) is currently the second most common neurodegenerative disorder after Alzheimer’s disease (AD), affecting 100.000 people in Spain and more than 4 million people worldwide. Being ...
Spinosa, Vittoria (Date of defense: 2019-12-16)
Perception can be considered as the bridge necessary to interact with the surroundings. Indeed, through our senses we are continuously exchanging information between the physical world around us and our ...
Herraiz Martínez, Adela (Date of defense: 2016-12-20)
Background Ageing is a risk factor that promotes common cardiovascular diseases such as atrial fibrillation (AF) or heart failure (HF), which in turn are associated with pathological changes in ...
Nhampossa, Tacilta Helena Francisco (Date of defense: 2013-12-20)
The objective of this thesis is to improve our understanding of the epidemiology of diarrhea, particularly to estimate the population-based burden, microbiologic etiology and adverse clinical consequences ...
Jiménez Flores, Lizbeth Minerva (Date of defense: 2018-11-09)
Gastric cancer (GC) is one of the most common types of cancer in the Western World and accounts for over 700,000 deaths every year worldwide. The prognosis is dismal, with an average 5-year survival ...