González Foruria, Iñaki (Date of defense: 2018-01-17)
This thesis includes two projects that evaluate the relationship between oxidative stress, the ADAM17/Notch signaling pathway, fibrosis and immunological dysfunction in the pathogenesis of endometriosis. The ...
Krasheninnikova, Maria Alieva (Date of defense: 2012-11-09)
Lately adipose tissue mesenchymal stem cells (hAMSCs) have emerged as cellular vehicles for therapy of solid tumors, due to their ease of isolation and manipulation, and wound/tumor homing capacity. ...
Medina Alcaraz, Juan Carlos (Date of defense: 2018-12-10)
Depression is one of the most prevalent disorders and one of the leading causes of disability worldwide. Regarding economic implications, depressive disorders have also a large impact on health budgets ...
Mariani, Francesco (Date of defense: 2016-07-05)
Although sygma-aryl and sygma-vinylpalladium(II) complexes are commonly used as electrophiles in C—C bond forming reactions, recent research has demonstrated that the same palladium intermediates can ...
Iglesias Platas, Isabel (Date of defense: 2012-03-05)
BACKGROUND: Fetal growth is a complex process which depends on nutrient and oxygen availability and transport from the mother to the fetus across the placenta. This involves hormones and growth factors ...
Angulo Urarte, Ana (Date of defense: 2017-02-24)
Class IA PI3K (PI3K) functions have been widely investigated over the last two decades. PI3K signalling is located at the crossroads of many cell surface receptors sending signals to coordinate multiple ...
Eibes González, Susana (Date of defense: 2016-09-13)
Mitosis is a tightly regulated process that aims to ensure the correct distribution of the chromosomes between the two newly generated cells. Many protein kinases have been defined as essential for this ...
Ghirardi, Elena (Date of defense: 2016-07-28)
The first objective of this Thesis was the study of the preparation of octhydro-1H-cyclopenta[b]pyridines and octahydro-1H-indoles, through the synthesis of (R)-phenylglycinol derived tricyclic lactams. ...
Escobedo Pascual, Albert (Date of defense: 2014-11-06)
Nedd4L is a HECT-type E3 ubiquitin ligase (it covalently binds ubiquitin molecules before transferring them to the final substrate). Ubiquitination is a posttranslational modification (PTM) that labels ...
Domenech Pena, Arnau (Date of defense: 2013-12-03)
It is estimated that within a few years chronic obstructive pulmonary disease (COPD) will be the third leading cause of death worldwide. The morbidity and mortality associated with COPD are due, in part ...