Ottino González, Jonatan (Date of defense: 2019-04-25)
Overweight and stress interact in complex ways. Excess weight promotes chronic low-grade inflammatory states that can mobilise the hypothalamic-pituitary-adrenal (HPA) axis. HPA axis activation resulting ...
Siles Mena, Laura (Date of defense: 2017-06-01)
ZEB1 is a transcription factor best known for its role in cancer progression and metastasis. It is also expressed during embryonic development of different tissues although its function and mechanism ...
Núñez Álvarez, Yaiza (Date of defense: 2017-07-26)
HDAC11 is the newest member of the histone deacetylase (HDAC) family and one of the less studied. Its expression was described to be enriched in skeletal muscle tissues from the first moment of its ...
Ariño Rodríguez, Helena (Date of defense: 2017-03-28)
This thesis focuses on antibodies against the glutamic acid decarboxylase (GAD-ab) in neurological disorders. GAD-ab were first identified in 1988 in the serum and CSF from one patient with stiff-person ...
Mestre-Bach, Gemma (Date of defense: 2019-03-04)
Dimensional theoretical models suggest that gambling disorder and eating disorders have two essential shared risk factors: impulsivity and compulsivity. In order to delve into the association between ...
Morcelle Magaña, Carmen (Date of defense: 2017-09-19)
In most human cancers, the c-Myc transcription factor is deregulated and/or its levels are elevated, particularly in colorectal cancer (CRC). Earlier studies suggested a direct relationship between ...
Sotillo Rodríguez, Fernando (Date of defense: 2018-02-16)
Lysinuric Protein Intolerance (LPI, MIM #222700) is a rare autosomic disease caused by mutations in SLC7A7 gene. Hallmarks of LPI are malabsorption and deficient renal reabsorption of cationic amino ...
Corraliza Márquez, Ana Maria (Date of defense: 2019-10-02)
Crohn’s disease [CD] is a chronic inflammatory disease of the intestinal tract with considerable heterogeneity among affected patients in terms of disease phenotype and therapeutic responses. Despite ...
Sanchez Delgado, Marta (Date of defense: 2018-05-31)
Genomic imprinting is an epigenetic phenomenon resulting in the monoallelic expression of a subset of genes in a parent-of-origin-specific manner. In general, the promoters of these transcripts contain ...
Pascual Domingo, Rosa (Date of defense: 2018-07-03)
The mammary gland develops postnatally and is remodeled, during each estrous cycle and pregnancy, through very dynamic expansions and involutions of its polarized epithelial tree. Moreover, the mammary ...