García Lema, Jorge (Date of defense: 2020-10-08)
Adenosine deaminase acting on tRNAs (ADAT) is a eukaryotic heterodimer, composed by ADAT2 and ADAT3, that catalyses the deamination of adenosine-to-inosine in the anticodon loop of tRNAs. ADAT proteins ...
Peña Lozano, Elionora (Date of defense: 2020-11-13)
Based on the background showing i) that obesity have a polygenic nature with the implication of different genes of minor effect and lifestyle factors; ii) the high variability between individuals in ...
Zimmermann, Fabian (Date of defense: 2021-11-24)
The microtubule nucleator γ-tubulin ring complex (γTuRC) is essential for the function of microtubule organizing centers such as the centrosome. Since its discovery over two decades ago, γTuRC has evaded ...
Arafaty, Nazanin (Date of defense: 2021-04-30)
The topic of this thesis is to investigate the polyamine metabolism during defense response in Arabidopsis thaliana. I mainly focused on the alteration of polyamine metabolism in different layers of ...
Aguilar Recarte, David (Date of defense: 2021-09-20)
Type 2 diabetes (T2D) is a multifactorial disease that comprises metabolic defects in multiple organs. Several studies have shown that the presence of a chronic low-state inflammatory process induces ...
Paz Domínguez, Joel (Date of defense: 2021-12-14)
Despite decades of work, the molecular requirements underlying microtubule- organizing center (MTOC) formation at the centrosome remain obscure. Progress is hindered by the complexity of this organelle, ...
Rasti Zaghiyan, George (Date of defense: 2021-09-20)
The Sirtuin family of NAD+-dependent enzymes plays a key role in the maintenance of genome integrity upon stress. Sirtuins coordinate the response to different forms of stress at different levels and ...
Marín-Valls, Roser (Date of defense: 2021-10-01)
Biocatalysis gained importance in the latter half of the 20th century and its application in the pharmaceutical, food and chemical industries continues to expand nowadays. Enzymes catalyze chemical ...
Codony Soler, Xavier (Date of defense: 2022-06-02)
The sigma-1 receptor is a chaperone that is primarily expressed in the mitochondria-associated endoplasmic reticulum (MAM). It was cloned years ago from different tissues of various species ...
Scaffidi, Salvatore (Date of defense: 2021-01-15)
Once a target is identified and characterized, the long pathway to develop a drug starts. In this process, biophysical methods have an important part to play and nowadays are firmly combined at several ...