López Molina, Laura (Date of defense: 2022-06-17)
[spa] La enfermedad de Huntington (EH) es una enfermedad neurodegenerativa hereditaria causada por la mutación de la huntingtina (mHtt) que ocasiona síntomas motores, cognitivos y psiquiátricos. La ...
Dahdah, Norma (Date of defense: 2022-07-27)
[eng] Obesity has become exceedingly pervasive, a resultant of amplified food availability and reshaped human behavior stimulated by urbanization. It poses as a major challenge for human metabolic ...
Alonso Martínez de Marañón, Josune (Date of defense: 2022-12-01)
[spa] La terapia actual contra la mayoría de los cánceres está basada en el uso de agentes que dañan el ADN, como la quimioterapia o la radioterapia, que erradican las células tumorales proliferantes. ...
Martínez Martínez, Arturo (Date of defense: 2022-12-02)
[spa] HERC1 es una E3 ubicuitina ligasa de la familia HECT. Mutaciones en el gen de HERC1 han sido relacionadas con diferentes tipos de cánceres y enfermedades neurodegenerativas. En esta tesis, ...
Loeck, Maximilian (Date of defense: 2022-09-16)
[eng] The blood-brain barrier (BBB) is a major obstacle for the treatment of neurological diseases such as common Parkinson’s disease or rare lysosomal storage disorders (LSDs). LSDs are characterised ...
Ciscar García, Marina (Date of defense: 2022-10-03)
[spa] Durante el proyecto de tesis se han realizado dos proyectos: Por un lado, se ha investigado la biología de la vía de señalización de RANK en adenocarcinomas de mama humanos. Además, se han ...
Castellá Giner, Moisés (Date of defense: 2023-09-29)
[emg] Alternative splicing (AS) is a gene expression regulatory mechanism that enables generation of multiple mRNA isoforms from a single gene which commonly are translated into proteins. This mechanism ...
Tello Velasco, Daniel (Date of defense: 2023-09-19)
[eng] For this purpose, Spatial Analysis of Functional Enrichment (SAFE) framework was proposed to uncover functional regions in a network by embedding it in 2-dimensions (2D) using the Spring embedding ...
Raimondi, Giulia (Date of defense: 2020-06-08)
The general goal of this thesis has been to progress oncolytic adenovirus therapy for PDAC, by the incorporation of novel preclinical models to test for patient-specific responses and the generation of ...
Jesús Gil, Carmen de (Date of defense: 2021-06-01)
Psoriasis is a common immune-mediated inflammatory skin condition affecting around 2% of the population worldwide. Different disease subtypes have been described regarding their specific clinical ...