Panarello, Silvia (Date of defense: 2021-12-15)
Photopharmacology has the main purpose to allow the control of protein activity with light. The most exploited strategy used to achieve this objective is the freely diffusible photopharmacology and it ...
Gómez Santacana, Xavier (Date of defense: 2016-05-13)
Metabotropic glutamate receptors (mGlu receptors) are class C GPCRs widely distributed through the CNS and considered pharmacological targets for neurologic disorders, such as neuropathic pain and ...
Alcaide López, Anna (Date of defense: 2012-12-18)
Sphingolipids are essential biomolecules for the physiological cell function. In addition to its structural role in cell membranes, these lipids have also crucial functions in signal transduction and ...
Font Ingles, Joan (Date of defense: 2017-06-09)
Pain is one of the main medical problems that in several cases results into a chronic disease with limited effective treatment, thus the discovery of new drugs to fight against constitutes a big challenge ...
Borràs Tudurí, Roser (Date of defense: 2018-07-06)
The Immune System (IS) is a complex collection of tissues, organs, cells and molecules to defense the body against threatens. IS is organized into two lines of defense: innate immunity which acts in a ...
Trapero Puig, Ana (Date of defense: 2011-03-21)
Els malalts de Gaucher manquen de l’activitat normal de l’enzim lisosomal Glucocerebrosidasa (GCase), una β–glucosidasa que hidrolitza l’enllaç glicosídic entre la glucosa i la ceramida, i són incapaços ...
Matabosch Geronès, Xavier (Date of defense: 2006-12-21)
En els últims anys s'ha demostrat que els lípids no són només components estructurals de la membrana plasmàtica sinó que a més a més aquests desenvolupen diferents funcions cel·lulars. Concretament s'ha ...
Pittolo, Silvia (Date of defense: 2016-01-29)
In the brain events happen in the scale of milliseconds, and the fine processes of neurons and neuroglia are highly compartmentalized at a microscopic level. These exclusive features of the brain define ...
Monlleó Mas, Ester (Date of defense: 2016-11-25)
Gaucher disease (GD) is one of the most prevalent lysosomal storage diseases.A mutation on gene gba1 generates a misfolded enzyme acid β-glucosidase. Due to this, this enzyme is not properly transported ...
Duran Corbera, Anna (Date of defense: 2022-04-22)
G protein-coupled receptors (GPCRs) are a large family of membrane proteins responsible for signaling transduction processes. Due to their roles in modulating essential physiological functions, GPCRs ...