Moreno Monasterio, Marta (Date of defense: 2015-02-18)
The main goal of this PhD thesis was to understand the mechanisms underlying GBM tumor formation and progression, with a special emphasis on the study of factors that have a role in normal NSC biology, ...
Grandes Vilaclara, Mª Eugenia (Date of defense: 2008-06-18)
The aim of this 4 year long work was to study the Connexin32 (Cx32), a protein that forms hemichannels anchored in the plasma membrane. Two hemichannels of adjacent cells form a gap junction. Mutations ...
Moreno Càceres, Joaquim (Date of defense: 2016-01-18)
The transforming growth factor-beta (TGF-β) is a cytokine involved in many physiological and pathological processes. Its dual role has been described in the liver, where it can either induce pro- or ...
Adrião Camoez, Marina (Date of defense: 2016-02-08)
Infections by methicillin-resistant Staphylococcus aureus (MRSA) are still an important cause of morbidity and mortality worldwide. Health-care associated infections, especially bacteremia, often represent ...
Cordero Casanovas, Alex (Date of defense: 2015-10-23)
Esta tesis doctoral se ha centrado en el paper de la vía de RANK y RANKL, que ha emergido durante los últimos años como una vía crucial en el desarrollo de la glándula mamaria y cáncer de mama. La ...
Sala Hojman, Ada (Date of defense: 2016-07-15)
LIF is a pleiotropic cytokine that can act as an immunomodulatory factor in different biological processes, such as embryo implantation, organ transplantation tolerance and multiple sclerosis. Here, we ...
Arroyo Sánchez, Rodrigo (Date of defense: 2014-06-20)
Network and systems biology disciplines could revolutionize the study of complex diseases by taking proteins back to their context, considering a much broader perspective of their environment without ...
Torrens Fontanals, Laura (Date of defense: 2022-03-07)
[eng] 1. HYPOTHESES. Primary liver cancer is the sixth most commonly diagnosed cancer and the second leading cause of cancer-related death worldwide2,3. Around 90% of cases correspond to hepatocellular ...
Gómez Puerta, José Alfredo (Date of defense: 2007-10-03)
The antiphospholipid syndrome (APS) is an acquired prothrombotic syndrome characterized by venous or arterial thromboses and pregnancy morbidity. It can present as primary APS without any discernable ...
Gonzàlez Juncà, Alba (Date of defense: 2013-11-15)
The TGF-beta oncogenic effect has been widely studied. In glioma, TGF-beta has an oncogenic role increasing cell proliferation and glioma-initiating cell (GIC) self-renewal capacity. During the investigation ...