Fàbrega Santamaria, Anna (Date of defense: 2010-11-24)
INTRODUCTION Quinolones are potent and broad spectrum antibacterial agents and, among them, several fluoroquinolones, such as ciprofloxacin, are the treatment of choice against several human infections. ...
Esteve Arenys, Anna (Date of defense: 2017-12-22)
Lymphomas are a heterogeneous group of tumors characterized by the proliferation of lymphocytes predominantly in lymphoid structures but also in extranodal tissues. More than 90% of patients are ...
Recasens Zorzo, Clara (Date of defense: 2018-06-19)
Constitutive activation of the chemokine receptor CXCR4 is associated with tumor progression, invasion and resistance to treatment. Overexpression of CXCR4 in diffuse large B-cell lymphoma (DLBCL) confers ...
Zubeldia Plazaola, Arantzazu (Date of defense: 2015-12-18)
One of the key events in the evolution of breast cancer is the transition from ductal carcinoma in situ (DCIS) to invasive ductal carcinoma (IDC). The myoepithelial cell layer is disrupted in this ...
Guerrero Hernández, Martina (Date of defense: 2019-02-19)
The tumor microenvironment (TME) is gaining momentum due to its contribution to cancer progression and therapy resistance. This TME has a direct crosstalk with tumor cells that involves the activation ...
Moutinho, Cátia (Date of defense: 2014-05-23)
Although chemotherapeutic drugs are widely used in order to improve the cancer outcome, drug resistance remain the most unpredictable factor affecting chemotherapy and a major impediment to successful ...
Hernández Madrigal, Miguel (Date of defense: 2022-06-17)
Tumours grow in a self-imposed hypoglycaemic microenvironment due to their exacerbated metabolic needs. To thrive in these harsh conditions, malignant cells must adapt their own metabolic routes and ...
Llobet Cucalón, Lara Isabel de (Date of defense: 2013-11-22)
1. Generation and characterization of a radioresistant cell line In the first part of this project of Thesis, we subjected culture cells to fractionated radiation and clonal selection, to obtain a ...
García de Albéniz, Xabier (Date of defense: 2015-04-15)
We studied the mechanisms driving the metastatic spread in colorectal cancer (CRC), focusing in the MAPK pathway. We developed in vivo a highly metastatic cell line using a KRAS-mutated cell line (SW620) ...
Burgos Rincón, Felip (Date of defense: 2013-09-12)
INTRODUCTION The deployment of new health care models based on the coordination between different levels is a priority at European level to manage the dysfunctions generated by health and social ...