Ara mostrant els elements 21-30 de 37
González Burón, Helena (Data de defensa: 2014-03-19)
The human Tousled-like kinases 1 and 2 (TLKs) are predicted serine/threonine kinases that show maximal activity in S phase and are transiently inhibited by the DNA damage response (DDR). Both TLKs ...
García Lizarribar, Andrea (Data de defensa: 2022-01-28)
In vitro engineered three-dimensional tissue models are attracting an increasing interest due to their potential applications in preclinical assays. On the one hand, they are an alternative to the high ...
Ortiz Barahona, Vanessa (Data de defensa: 2022-04-01)
The general aim of this thesis is to identify and characterize if there are DNA methylation patterns giving rise to cancer-related m5C RNA modification defects, potentially promoting malignant transformation ...
Ahumada Brena, David Ricardo (Data de defensa: 2021-07-09)
[eng] Mammalian Inhibitor-of-kappa-B (IκBs) proteins exert their main function as negative regulators of NF-κB, a central signaling pathway controlling immunity and inflammation. An alternative chromatin ...
Serra Camprubí, Queralt (Data de defensa: 2023-07-27)
[eng] The field of cancer treatment has shifted towards personalized medicine, driven by advancements in understanding molecular and genetic abnormalities and identifying specific targets within cancer ...
Boix Sánchez, Olga (Data de defensa: 2022-10-11)
[eng] Recent advances in computational analyses, peptidomics and ribosome profiling have revealed that many regions previously annotated as non-coding are in fact translated into a myriad of bioactive ...
Casalà Albacete, Carla (Data de defensa: 2013-07-12)
Los neuroblastomas (NB), ganglioneuroblastomas (GNB) y ganglioneuromas (GN) conforman el grupo de los tumores neuroblásticos (TN). Se trata de un grupo muy heterogéneo de tumores del desarrollo que ...
Martín Abad, Berta (Data de defensa: 2013-12-13)
L’epigenètica fa referència als canvis heretables en l'expressió gènica que no són causats per alteracions en la seqüència d'ADN. La metilació de la citosina en el dinucleòtid CpG és una de les modificacions ...
Moncunill Massaguer, Cristina (Data de defensa: 2015-07-23)
The pro-apoptotic effects of two new drugs have been studied for the development of new strategies for cancer treatment. On the one hand, we proved that AICAR induces apoptosis in an AMPK- and p53-independent ...
Franco Valls, Héctor (Data de defensa: 2022-05-26)
SNAIL1 is a transcription factor with roles in repression of epithelial genes and enhancement of mesenchymal genes. As such, it plays a key role in Epithelial-to-mesenchymal transition and in fibroblast ...