Oriolo, Giovanni (Date of defense: 2019-09-12)
INTRODUCTION. Sickness behavior is a highly organized adaptive strategy elicited by inflammation to support the organism’s defense against pathogens. It is characterized by changes in behavior, mood and ...
Vilaplana Saiz, Marta (Date of defense: 2021-01-22)
This thesis shows the research carried out on two specific diseases: familial hypercholesterolemia, which is included within the cardiovascular diseases group, and cancer. These diseases are the major ...
Recalde-Percaz, Leire (Date of defense: 2021-06-30)
Metastases are considered the last stage of tumour progression and the main cause of death associated to solid tumours. There are no effective treatments for metastasis which remain non- curable with ...
Marrone, Giusi (Date of defense: 2014-06-27)
Increased intrahepatic vascular resistance (IHVR), mainly due to elevated vascular tone together with the maturation of hepatic fibrosis and the drop of the hepatic endothelial function, is the main ...
Rey Jurado, Emma (Date of defense: 2013-02-11)
Tuberculosis (TB) remains a global threat worldwide with nearly nine million incident cases of TB. The emergence of M. tuberculosis resistance to antituberculous drugs has led to the need for careful ...
Petrillo, Giovanna (Date of defense: 2017-06-28)
The rapid progress in structural and molecular biology over the past fifteen years has allowed chemists to access the structures of enzymes, of their complexes and of engineered variants. This wealth ...
Garrido Martínez, María (Date of defense: 2012-12-14)
To study biological systems through the specific labeling of biomolecules by chemical reactions has grown interest in the last few years. In order to perform chemical reactions in living systems, it is ...
Bioque Alcázar, Miquel (Date of defense: 2013-10-14)
Around 3% of the general population suffers a first episode of psychosis (FEP). The population of FEPs represents a unique opportunity to study psychotic disorders in general and schizophrenia in ...
Márquez Arrico, Julia E. (Date of defense: 2017-07-18)
Dual Diagnosis (DD) refers to the co-existence of a Severe Mental Illness (SMI) and a Substance Use Disorder (SUD) in the same individual. The comorbid prevalence of these two diagnoses is very common, ...
Crosas Molist, Eva (Date of defense: 2015-02-09)
Reactive oxygen species (ROS) are short-lived, highly electrophilic molecules generated by the partial reduction of oxygen to form superoxide, hydrogen peroxide and hydroxyl radical as well as other ...