Díaz Perlas, Cristina (Date of defense: 2018-03-07)
Peptides play a critical role in human physiology and harbour a huge potential as therapeutic agents. In this thesis, new peptides have been discovered as ligands for the epidermal growth factor (EGF) ...
Cruz Gatell, Montse (Date of defense: 2003-11-20)
La hipótesis amiloide de la enfermedad de Alzheimer fue la base, hace algunos años, para el desarrollo de una línea de investigación cuyo objetivo principal es la obtención de pequeñas moléculas peptídicas ...
Rodríguez Ropero, Sergio (Date of defense: 2003-05-12)
El comportament reproductor en moltes espècies d'insectes implica l'alliberament per part de la femella d'una sèrie de compostos químics volàtils, anomenats feromones, els quals són detectats de forma ...
Mendieta Martínez, Laura (Date of defense: 2014-06-06)
Proteases are involved in a high number of diseases, and thus, are relevant targets. For that reason our main goal was the discovery of protease inhibitors as therapeutic agents. We focused our study ...
Rodríguez Mías, Ricard Aleix (Date of defense: 2006-10-05)
Nuclear Magnetic Resonance has experienced an increasing interest in the drug discovery field that has led to its wide use on nearly every stage of drug development. For this reason, during the present ...
Sabidó Aguadé, Eduard (Date of defense: 2008-11-24)
Actualment, les proteïnes implicades en la biosíntesi i la degradació dels neuropéptidos estan cobrant un gran interès com a possibles noves dianes terapèutiques ja que determinen els nivells de neuropèptid ...
Oller Salvia, Benjamí (Date of defense: 2015-05-18)
Brain delivery is a major unmet challenge because most drugs cannot cross the blood-brain barrier (BBB). Despite the restrictive nature of this barrier, brain vasculature reaches essentially every neural ...
Gordo Villoslada, Susana (Date of defense: 2008-06-30)
Protein-protein interactions are essential in biological processes and thus, they have become very promising therapeutic targets. Nevertheless, the artificial modulation of protein complexes remains a ...
Le Roux, Anabel-Lise (Date of defense: 2015-11-18)
c-Src is the leading member of the Src family of non-receptor tyrosine kinases, which are involved in many signaling pathways. Its deregulation affects cell migration, proliferation and survival. c-Src ...
Serra Vidal, Bernat (Date of defense: 2014-05-27)
Alzheimer’s disease (AD) is a neurodegenerative disorder which major risk factor is age. Current drugs only offer symptomatic alleviation in AD, thus a disease-modifying treatment is urgent. The amyloid-β ...