Bassani, Nicklas (Date of defense: 2017-12-15)
Antiangiogenic drugs are used clinically for treatment of different types of cancers and in the case of renal cell carcinoma (RCC) are now standard first-line treatments (Rini, 2009). Nevertheless, these ...
Yoldi, Guillermo (Date of defense: 2018-10-23)
The discovery that RANK signaling mediates the protumorigenic role of progesterone in the mammary gland and its association with poor prognosis in breast cancer has opened the possibility of using RANKL ...
Rhodes Cabrerizo, Ana Carolina (Date of defense: 2017-06-21)
ANTECEDENTES: El carcinoma hepatocelular (CHC) es el cáncer de hígado más frecuente y la sexta neoplasia con mayor incidencia mundial. Constituye la tercera causa de muerte por cáncer y la decimosexta ...
Vidal Crespo, Anna (Date of defense: 2017-04-28)
In this thesis we have focused on two novel therapeutic strategies that target the crosstalk between the tumor cells and the microenvironment. Chronic lymphocytic leukemia (CLL) remains an incurable ...
Rosich Moya, Laia (Date of defense: 2014-06-05)
La via de supervivència PI3K/AKT/mTOR es troba constitutivament activada en molts tumors, fet que ha afavorit el desenvolupament de nombrosos inhibidors al considerar-se una possible opció terapèutica. ...
Herrera Camacho, Antonio (Date of defense: 2015-11-06)
El meduloblastoma es un tumor cerebral maligno localizado en la fosa posterior del cráneo, con una muy alta incidencia en niños. Hasta cuatro distintos subgrupos de meduloblastomas pueden ser definidos ...
Mateo Campins, Patricia (Date of defense: 2018-10-17)
La present tesi doctoral està enfocada al desenvolupament de noves petites molècules dirigides a diferents dianes del càncer. Els descobriments recents sobre la seqüenciació genòmica del càncer han ...
Zuazo Gaztelu, Iratxe (Date of defense: 2018-11-23)
Tumor progression is a complex conundrum of events that involve not only tumor cells, but also their surrounding microenvironment. Accounting to the natural dependency of tumors on angiogenesis, its ...
Llorente Lope, Alicia (Date of defense: 2021-03-23)
Metastatic breast cancer (BCa) is the leading cause of death in BCa patients. Current therapies for BCa aim at cell proliferation and, therefore, latent disseminated cells are able to escape treatment. ...
Rijo Mora, Enrique Antonio (Date of defense: 2017-09-26)
INTRODUCCIÓN: MICA (Major histocompatibility complex I Chain related proteins to gen A) se expresa como respuesta al estrés celular en procesos neoplásicos, inflamatorios, infecciones virales y ...