Vidal Crespo, Anna (Date of defense: 2017-04-28)
In this thesis we have focused on two novel therapeutic strategies that target the crosstalk between the tumor cells and the microenvironment. Chronic lymphocytic leukemia (CLL) remains an incurable ...
Zuazo Gaztelu, Iratxe (Date of defense: 2018-11-23)
Tumor progression is a complex conundrum of events that involve not only tumor cells, but also their surrounding microenvironment. Accounting to the natural dependency of tumors on angiogenesis, its ...
Llorente Lope, Alicia (Date of defense: 2021-03-23)
Metastatic breast cancer (BCa) is the leading cause of death in BCa patients. Current therapies for BCa aim at cell proliferation and, therefore, latent disseminated cells are able to escape treatment. ...
Martínez Cartró, Míriam (Date of defense: 2021-10-25)
Advances in structural and molecular biology have increased the knowledge of relevant and undrugged targets and have favoured the rational development of novel drugs through structure- based ...
Benítez, Sandra (Date of defense: 2021-01-13)
Receptor activator of nuclear factor kappa-β ligand (RANKL) and its receptor RANK are key mediators of bone resorption1,2. RANKL, its receptor RANK and its natural decoy receptor OPG, which is a competitive ...
Noguera-Castells, Aleix (Date of defense: 2022-01-31)
Modern oncology conceives solid tumours as organs by themselves, meaning that not only should the behaviour of cancer cells to be considered and evaluated therapeutically, but also the so-called tumour ...
Manzano Muñoz, Albert (Date of defense: 2022-12-15)
[eng] Personalized medicine has emerged to improve cancer treatment beyond classical approaches. The identification of genetic mutations by molecular analyses dominate personalized medicine initiatives ...
Moreno Monasterio, Marta (Date of defense: 2015-02-18)
The main goal of this PhD thesis was to understand the mechanisms underlying GBM tumor formation and progression, with a special emphasis on the study of factors that have a role in normal NSC biology, ...
Sala Hojman, Ada (Date of defense: 2016-07-15)
LIF is a pleiotropic cytokine that can act as an immunomodulatory factor in different biological processes, such as embryo implantation, organ transplantation tolerance and multiple sclerosis. Here, we ...
Rodríguez García, Alba (Date of defense: 2015-02-27)
Oncolytic adenoviruses represent an appealing therapeutic approach to treat cancer regarding its capability to infect and kill selectively tumor cells without damaging normal tissues. Tumor targeting ...