Martín Liberal, Juan Jesús (Date of defense: 2016-11-07)
Sarcomas are a group of malignancies characterized by their bad prognosis and the absence of effective treatments. Median survival of advanced sarcoma patients is only one year in spite of treatment. ...
Nadal Sanmartin, Cristina (Date of defense: 2007-07-24)
1 INTRODUCCIÓN<br/><br/>El cáncer colorrectal (CCR) es la tercera causa de diagnóstico de cáncer en todo el mundo. El 11-27% de pacientes se diagnostican en estadio avanzado o metastático. De los ...
Sostoa Pomés, Jana de (Date of defense: 2019-05-31)
Oncolytic virus (OV)-based therapies have an emerging role in the treatment of solid tumors, involving both direct cell lysis and immunogenic cell death. Nonetheless, tumor- associated stroma limits the ...
Fajardo Calderón, Carlos Alberto (Date of defense: 2017-05-19)
Oncolytic adenoviruses that selectively replicate in cancer cells while sparing normal tissue have gained considerable attention as novel anticancer drugs. However, clinical trials with these viruses ...
Félez Sánchez-Ocaña, Marta (Date of defense: 2017-06-29)
Papillomaviruses (PVs) are a numerous family of small dsDNA viruses infecting virtually all mammals. PVs cause infections without triggering a strong immune response, and natural infection provides ...
Albert Colomer, Nerea (Date of defense: 2021-01-18)
Tumor-stroma crosstalk is essential for PDAC formation. Therefore, the stroma, and specifically the carcinoma-associated fibroblasts (CAFs), are the target of therapeutic alternatives to treat highly ...
Soucek, Richard (Date of defense: 2014-01-28)
The study deals with the synthesis and biological activity of 4 different antitumours: Tetrahydro-[1,4]-dioxanisoquinolines, combretastatin A-4, dioxancarbazoles and resveratrol analogues. This study ...
Banjer, Hamsa Jameel (Date of defense: 2018-07-06)
Transportome alterations have been associated with oncogenesis. The loss of human Concentrative Nucleoside Transporter 1 (hCNT1) during carcinogenesis seems to be a relatively common event in tumors and ...
Coll San Martín, Laia (Date of defense: 2021-11-29)
Cancer was reported as the second leading cause of death in 2018 by the World Health Organisation. Cancer is defined as the set of diseases that proceeds in multiple phases generating a transformation ...
Aparicio García, María (Date of defense: 2020-12-09)
[eng] The arrival of antiangiogenic therapies represented a huge advance in the treatment of different tumors, such as renal carcinoma. However, despite initial good results, some tumors were able to ...