Mazuelas Gallego, Helena (Date of defense: 2021-01-28)
Neurofibromatosis type 1 (NF1) is a genetic disease caused by inherited mutations in the NF1 gene. NF1 is a cancer predisposition syndrome, and the disease’s hallmark is the appearance of tumors of the ...
García de Albéniz, Xabier (Date of defense: 2015-04-15)
We studied the mechanisms driving the metastatic spread in colorectal cancer (CRC), focusing in the MAPK pathway. We developed in vivo a highly metastatic cell line using a KRAS-mutated cell line (SW620) ...
Díaz Gay, Marcos (Date of defense: 2019-11-25)
Colorectal cancer (CRC) is one of the malignant neoplasms with higher incidence and mortality in Spain, Europe and worldwide. As a complex disease, both environmental and genetic factors influence CRC ...
Figueiredo, Ana Raquel Martins (Date of defense: 2017-06-09)
Pericytes (PCs) are important regulators of the vascular development promoting vessel growth and stabilization. They have recently emerged as a therapeutic target to promote or inhibit angiogenesis. ...
Morcelle Magaña, Carmen (Date of defense: 2017-09-19)
In most human cancers, the c-Myc transcription factor is deregulated and/or its levels are elevated, particularly in colorectal cancer (CRC). Earlier studies suggested a direct relationship between ...
Farrera Sal, Martí (Date of defense: 2020-10-30)
The oncolytic viruses (OVs) preferentially infect tumor and selectively replicate in cancer cells without harming normal tissues. OVs have been tested in clinical trials as monotherapy or combined with ...
Duch Gili, Paula (Date of defense: 2022-03-14)
Increased expression of TIMP-1 is associated with poor prognosis in virtually all cancer types, including lung cancer. However, how TIMP-1 is regulated in lung cancer and how it drives tumor progression ...
Lewis, Michael (Date of defense: 2022-11-11)
[eng] Transcriptional regulation is a multifaceted and fundamental process, which underpins normal physiology, and its dysregulation is associated to numerous pathologies. Using two inherently different ...
Coll Iglesias, Laura (Date of defense: 2022-11-23)
[eng] Endometrial cancer represents the most common cancer arising from the uterine cavity and there is little hope for patients with recurrent or metastatic disease. Prior studies of our group reported ...
Lacy Oliver, Francisco de Borja de (Date of defense: 2021-06-22)
[eng] Colorectal cancer is a major global public health issue. According to the 2018 Global Cancer Statistics, 1.8 million new cases of colorectal cancer are diagnosed worldwide, with almost 900,000 ...