Caballero Díaz, Daniel (Date of defense: 2018-02-09)
Hepatocellular Carcinoma (HCC) is one of the most common cancers. During hepatocarcinogenesis (a multistep process) there is a disruption of the balance between cell death and survival signalling pathways, ...
Candotti, Michela (Date of defense: 2016-12-09)
This work aims to analytically understand the impact of two diametric opposite environments on protein structure and dynamics and compared them to the most common solvent on earth: water. The first ...
Jiménez García, Brian (Date of defense: 2016-07-21)
Computing has pushed a paradigm shift in many disciplines, including structural biology and chemistry. This change has been mainly driven by the increase in performance of computers, the capacity of ...
Quiroga Álvarez, Xarxa (Date of defense: 2021-06-23)
Five years ago, I started walking this path that now seems like an entire life. Although everyone around tried to explain how this would feel, none of their explanations could have match what it has ...
Barradas Bautista, Didier (Date of defense: 2017-03-16)
Proteins are the embodiment of the message encoded in the genes and they act as the building blocks and effector part of the cell. From gene regulation to cell signalling, as well as cell recognition ...
Llamas Pámanes, Ernesto (Date of defense: 2017-09-15)
Chloroplasts provide plants with metabolic pathways that are unique among eu- karoytes, including the methylerythritol 4-phosphate pathway (MEP) for the pro- duction of isoprenoids essential for ...
Sánchez Martínez, Melchor (Date of defense: 2014-12-09)
Proteins are flexible entities, and thus move. Its function is closely related to the flexibility. To carry out any function is necessary a conformational change. As protein motions imply an exchange ...
Gomes, Tiago Lopes (Date of defense: 2019-11-05)
Signal transduction pathways are essential mechanisms that cells use to perform a myriad of biological processes that when aberrant, can cause serious diseases. Understanding the molecular basis of these ...
Calatayud Robert, Sara (Date of defense: 2021-12-20)
Proteins are composed of domains, a well-defined region within a protein that constitutes a stable, independently folding, compact structural unit, and that usually performs a specific function. During ...
Sfriso, Pedro (Date of defense: 2016-03-18)
Sequence, structure and dynamics are an indivisible tandem to understand protein function. Luckily, evolution imposed a hierarchical rational between that facilitates the analysis: dynamics are encoded ...